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Review
. 2021 Jul 5;8(3):265-270.
doi: 10.3390/dermatopathology8030032.

The Multiple Faces of Nodular Trichoblastoma: Review of the Literature with Case Presentation

Gerardo Cazzato  1 , Antonietta Cimmino  1 , Anna Colagrande  1 , Francesca Arezzo  2 , Lucia Lospalluti  3 , Sara Sablone  4 , Teresa Lettini  1 , Leonardo Resta  1 , Giuseppe Ingravallo  1
Affiliations
Review

The Multiple Faces of Nodular Trichoblastoma: Review of the Literature with Case Presentation

Gerardo Cazzato et al. Dermatopathology (Basel). .

Abstract

Trichoblastoma (TB) is a rare biphasic benign adnexal neoplasm originating from follicular germ cells but clinically, it can simulate basal cell carcinoma (BCC), making the diagnosis more difficult. There are several variants of Trichoblastoma and a good knowledge of these is essential for correct diagnosis and management. We report two new cases observed in the last year at our Pathological Anatomy Operative Unit, and conduct a careful review of the literature, from the first description of this lesion by Headington in 1970 to the most recent classifications.

Keywords: adnexal tumors; dermatopathology; skin; trichoblastoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Clinical features of the “Case 1” lesion.
Figure 2
Figure 2
(A) Clinical features of the “Case 2” lesion, well circumscribed, symmetrical, smooth bordered, skin-colored pinkish or brown, at the level of the passage from the tip to the right nasal wing. (B) Dermoscopic features of TB with arborizing vessels and teangiectasias.
Figure 3
Figure 3
Proliferation of numerous small and irregular nests of basaloid cells with no obvious connection to the epidermis (hematoxylin and eosin, original magnification, (A) 40× (B) 100×).
Figure 4
Figure 4
Proliferation of large nests of basaloid cells without connection to the epidermis (hematoxylin and eosin, original magnification, (A) 40× (B) 100×).
See this image and copyright information in PMC

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References

    1. Kamat G., Yelikar B., Shettar S., Karigoudar M.H. Pigmented trichoblastoma with sebaceous hyperplasia. Indian J. Dermatol. Venereol. Leprol. 2009;75:506–508. doi: 10.4103/0378-6323.55397. - DOI - PubMed
    1. WHO . WHO Classification of Tumours. 4th ed. Volume 11 WHO; Geneva, Switzerland: 2018.
    1. Fusumae T., Tanese K., Takeuchi A., Takasugi A., Kawakita R., Shiraishi J., Yoshida T. High-grade trichoblastic carcinoma arising through malignant transformation of trichoblastoma: Immunohistochemical analysis and the expression of p53 and phosphorylated AKT. J. Dermatol. 2019;46:57–60. doi: 10.1111/1346-8138.14686. - DOI - PubMed
    1. Patterson J. Weedon’s Skin Pathology. 5th ed. Elsevier; Amsterdam, The Netherlands: 2019.
    1. Headington J.T. Differentiating neoplasms of hair germ. J. Clin. Pathol. 1970;23:464–471. doi: 10.1136/jcp.23.6.464. - DOI - PMC - PubMed

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