The Multiple Faces of Nodular Trichoblastoma: Review of the Literature with Case Presentation

Abstract

Trichoblastoma (TB) is a rare biphasic benign adnexal neoplasm originating from follicular germ cells but clinically, it can simulate basal cell carcinoma (BCC), making the diagnosis more difficult. There are several variants of Trichoblastoma and a good knowledge of these is essential for correct diagnosis and management. We report two new cases observed in the last year at our Pathological Anatomy Operative Unit, and conduct a careful review of the literature, from the first description of this lesion by Headington in 1970 to the most recent classifications.

Keywords: adnexal tumors; dermatopathology; skin; trichoblastoma.

Figure 1

Clinical features of the “Case 1” lesion.

Figure 2

(A) Clinical features of the “Case 2” lesion, well circumscribed, symmetrical, smooth bordered, skin-colored pinkish or brown, at the level of the passage from the tip to the right nasal wing. (B) Dermoscopic features of TB with arborizing vessels and teangiectasias.

Figure 3

Proliferation of numerous small and irregular nests of basaloid cells with no obvious connection to the epidermis (hematoxylin and eosin, original magnification, (A) 40× (B) 100×).

Figure 4

Proliferation of large nests of basaloid cells without connection to the epidermis (hematoxylin and eosin, original magnification, (A) 40× (B) 100×).