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. 2021 Jul 14;5(3):36.
doi: 10.3390/vision5030036.

The Effect of Ocular Perfusion Pressure on Retinal Thickness in Young People with Presumed Systemic Hypotension

Naazia Vawda  1 , Alvin Munsamy  1
Affiliations

The Effect of Ocular Perfusion Pressure on Retinal Thickness in Young People with Presumed Systemic Hypotension

Naazia Vawda et al. Vision (Basel). .

Abstract

Low ocular perfusion pressure (OPP) may increase the risk of optic neuropathy. This study investigated the effects of OPP on the ganglion cell complex (GCC) and optic nerve head-retinal nerve fibre layer (ONH-RNFL) thickness in presumed systemic hypotensives (PSH). Fifteen participants with PSH and 14 controls underwent automated sphygmomanometry and Icare tonometry to calculate OPP: mean OPP (MOPP), systolic OPP (SOPP), and diastolic OPP (DOPP). ONH-RNFL and macula GCC thickness were evaluated using the Optovue iVue optical coherence tomographer. Statistical analysis comprised independent t-tests, the Mann-Whitney U test and binary logistic regression analysis. There was no significant difference when comparing ONH-RNFL and macula GCC thickness between both groups. Increased MOPP (OR = 0.51; 95% CI: 0.27-0.97; p = 0.039) and SOPP (OR = 0.79; 95% CI: 0.64-0.98; p = 0.035) were significantly associated with a decreased risk of reductions in GCC total thickness. Increased SOPP (OR = 0.11; 95% CI: 0.01-0.89; p = 0.027) was significantly associated with a decreased risk of reductions in the average ONH-RNFL thickness. The study found no significant retinal thickness changes in PSH's, in comparison to the controls. The study established that, by increasing MOPP and SOPP, there was a decreased risk of reductions in the total GCC thickness and average ONH-RNFL thickness. Higher SOPP may decrease the possibility of retinal thinning of the GCC and ONH-RNFL. However, higher MOPP may decrease the odds of thinning of the GCC before ONH-RNFL changes.

Keywords: ganglion cell complex; glaucoma; ocular perfusion pressure; retinal nerve fiber layer; systemic hypotension.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
An illustration of the ganglion cell complex (GCC) thickness map at the macula.
Figure 2
Figure 2
An illustration of the retinal nerve fibre layer thickness map around the optic nerve head.
Figure 3
Figure 3
A forest plot showing the effect size of the comparison of (ONH-RNFL) layers and (GCC-macula) layers between the PSH and control groups.
Figure 4
Figure 4
A forest plot showing associations between OPP and macula GCC.
Figure 5
Figure 5
A forest plot showing associations between OPP and ONH-RNFL.
Figure 6
Figure 6
Structural equation model (SEM) with the relationships between OPP and GCC and ONH-RNFL * (p < 0.05).
See this image and copyright information in PMC

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References

    1. Tham Y.C., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng C.Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology. 2014;121:2081–2090. doi: 10.1016/j.ophtha.2014.05.013. - DOI - PubMed
    1. Toro M.D., Brézin A.P., Burdon M., Cummings A.B., Kemer O.E., Malyugin B.E., Prieto I., Teus M.A., Tognetto D., Törnblom R., et al. Early impact of COVID-19 outbreak on eye care: Insights from EUROCOVCAT group. Eur. J. Ophthalmol. 2021;31:5–9. doi: 10.1177/1120672120960339. - DOI - PubMed
    1. Cheema A., Ahmad A., Moore D. Spectral Domain Optical Coherence Tomography in Glaucoma. [(accessed on 8 June 2021)];2021 American Academy of Ophthalmology. Available online: http://eyewiki.aao.org/Spectral_Domain_Optical_Coherence_Tomography_in_G....
    1. Kyari F., Abdull M.M., Bastawrous A., Gilbert C.E., Faal H. Epidemiology of glaucoma in sub-Saharan Africa: Prevalence, incidence and risk factors. Middle East Afr. J. Ophthalmol. 2013;20:111–125. doi: 10.4103/0974-9233.110605. - DOI - PMC - PubMed
    1. Kamińska A., Romano G., Rejdak R., Zweifel S., Fiedorowicz M., Rejdak M., Bajka A., Amato R., Bucolo C., Avitabile T., et al. Influence of Trace Elements on Neurodegenerative Diseases of The Eye—The Glaucoma Model. Int. J. Mol. Sci. 2021;22:4323. doi: 10.3390/ijms22094323. - DOI - PMC - PubMed

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