Reliability and validity of six-minute step test in patients with heart failure
- PMID: 34287574
- PMCID: PMC8289340
- DOI: 10.1590/1414-431X2020e10514
Reliability and validity of six-minute step test in patients with heart failure
Abstract
Exercise intolerance is the hallmark consequence of advanced chronic heart failure (HF). The six-minute step test (6MST) has been considered an option for the six-minute walk test because it is safe, inexpensive, and can be applied in small places. However, its reliability and concurrent validity has still not been investigated in participants with HF with reduced ejection fraction (HFrEF). Clinically stable HFrEF participants were included. Reliability and error measurement were calculated by comparing the first with the second 6MST result. Forty-eight hours after participants underwent the 6MST, they were invited to perform a cardiopulmonary exercise test (CPET) on a cycle ergometer. Concurrent validity was assessed by correlation between number of steps and peak oxygen uptake (V̇O2 peak) at CPET. Twenty-seven participants with HFrEF (60±8 years old and left ventricle ejection fraction of 41±6%) undertook a mean of 94±30 steps in the 6MST. Intra-rater reliability was excellent for 6MST (ICC=0.9), with mean error of 4.85 steps and superior and inferior limits of agreement of 30.6 and -20.9 steps, respectively. In addition, strong correlations between number of steps and CPET workload (r=0.76, P<0.01) and peak V̇O2 (r=0.71, P<0.01) were observed. From simple linear regression the following predictive equations were obtained with 6MST results: V̇O2 peak (mL/min) = 350.22 + (7.333 × number of steps), with R2=0.51, and peak workload (W) = 4.044 + (0.772 × number of steps), with R2=0.58. The 6MST was a reliable and valid tool to assess functional capacity in HFrEF participants and may moderately predict peak workload and oxygen uptake of a CPET.
Figures




Similar articles
-
Usefulness of oxygen uptake efficiency slope in a 6 min walk test in chronic heart failure.ESC Heart Fail. 2024 Aug;11(4):2055-2062. doi: 10.1002/ehf2.14754. Epub 2024 Mar 26. ESC Heart Fail. 2024. PMID: 38529745 Free PMC article.
-
The Six-Minute Step Test as a Predictor of Functional Capacity according to Peak VO2 in Cardiac Patients.Arq Bras Cardiol. 2021 May;116(5):889-895. doi: 10.36660/abc.20190624. Arq Bras Cardiol. 2021. PMID: 34008809 Free PMC article. English, Portuguese.
-
The six-minute step test as a predictor of cardiorespiratory fitness in obese women.Eur J Phys Rehabil Med. 2015 Dec;51(6):793-802. Epub 2015 May 26. Eur J Phys Rehabil Med. 2015. PMID: 26006079
-
Cardiopulmonary exercise testing criteria for advanced therapies in patients with heart failure.Heart Fail Rev. 2023 Nov;28(6):1297-1306. doi: 10.1007/s10741-023-10337-y. Epub 2023 Aug 30. Heart Fail Rev. 2023. PMID: 37644366 Free PMC article. Review.
-
Sacubitril/Valsartan in the Treatment of Heart Failure With Reduced Ejection Fraction Focusing on the Impact on the Quality of Life: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Cureus. 2023 Nov 11;15(11):e48674. doi: 10.7759/cureus.48674. eCollection 2023 Nov. Cureus. 2023. PMID: 38090453 Free PMC article. Review.
Cited by
-
Reliability and validity of the six-minute step test in assessing the functional capacity of hemodialysis patients.PeerJ. 2025 Jul 8;13:e19157. doi: 10.7717/peerj.19157. eCollection 2025. PeerJ. 2025. PMID: 40656948 Free PMC article. Clinical Trial.
-
Submaximal Field Walking Tests Applied in the Cardiopulmonary Assessment in Congenital Heart Diseases: A Systematic Review.Curr Pediatr Rev. 2024;21(1):56-66. doi: 10.2174/0115733963263592231127042702. Curr Pediatr Rev. 2024. PMID: 38251699
-
Feasibility of a Novel Augmented 6-Minute Incremental Step Test: A Simplified Cardiorespiratory Fitness Assessment Tool.JACC Adv. 2024 Jul 8;3(8):101079. doi: 10.1016/j.jacadv.2024.101079. eCollection 2024 Aug. JACC Adv. 2024. PMID: 39099774 Free PMC article.
-
Type 2 diabetes mellitus negatively affects the functional performance of 6-min step test in chronic heart failure: a 3-year follow-up study.Diabetol Metab Syndr. 2024 Sep 14;16(1):229. doi: 10.1186/s13098-024-01464-z. Diabetol Metab Syndr. 2024. PMID: 39272115 Free PMC article.
-
The six-minute step test can predict COPD exacerbations: a 36-month follow-up study.Sci Rep. 2024 Feb 13;14(1):3649. doi: 10.1038/s41598-024-54338-9. Sci Rep. 2024. PMID: 38351306 Free PMC article.
References
-
- Reis HV, Sperandio PA, Correa CL, Guizilini S, Neder JA, Borghi-Silva A, et al. Association of oscillatory ventilation during cardiopulmonary test to clinical and functional variables of chronic heart failure patients. Braz J Cardiovasc Surg. 2018;33:176–182. doi: 10.21470/1678-9741-2017-0158. - DOI - PMC - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous