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. 2021 Jul 21;326(9):868-869.
doi: 10.1001/jama.2021.11656. Online ahead of print.

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples

Timothy A Bates  1 , Hans C Leier  1 , Zoe L Lyski  1 , James R Goodman  2 , Marcel E Curlin  3 , William B Messer  1 , Fikadu G Tafesse  1
Affiliations

Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples

Timothy A Bates et al. JAMA. .

Abstract

This study examines the relationship between age and neutralizing antibody titers against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after 2 doses of the BNT162b2 vaccine.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Curlin reported receiving grants from the M.J. Murdock Charitable Trust and the Oregon Health & Science University Foundation for unrestricted COVID-19 research during the conduct of the study. Dr Tafesse reported receiving grants from Oregon Health & Science University Biomedical Innovation Program during the conduct of the study. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. SARS-CoV-2–Specific Antibody Levels
Enzyme-linked immunosorbent assay measurement of SARS-CoV-2 spike receptor–binding domain-specific antibody levels and association with age at time of vaccination for 50 participants 14 days after receiving their second vaccine dose. Prevaccination samples for all participants were below the limit of detection, indicating no prior exposure. Postvaccination samples displayed a significant negative association with age. The dotted line indicates the lower limit of quantification.
Figure 2.
Figure 2.. Neutralization of Live SARS-CoV-2 Clinical Isolates
Live virus neutralization of participant serum samples collected 14 days after the second vaccine dose. Neutralization experiments were performed with the USA-WA1/2020 strain and P.1 variant. Both show a significant negative association with participant age. The dotted line indicates the lower limit of quantification.
See this image and copyright information in PMC

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