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. 2021:1347:163-181.
doi: 10.1007/5584_2021_648.

Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers

Huseyin Beyaz  1 , Hasan Uludag  2   3   4 , Doga Kavaz  5   6 , Nahit Rizaner  5   6
Affiliations

Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers

Huseyin Beyaz et al. Adv Exp Med Biol. 2021.

Abstract

Breast cancer is the leading cancer type diagnosed among women in the world. Unfortunately, drug resistance to current breast cancer chemotherapeutics remains the main challenge for a higher survival rate. The recent progress in the nanoparticle platforms and distinct features of nanoparticles that enhance the efficacy of therapeutic agents, such as improved delivery efficacy, increased intracellular cytotoxicity, and reduced side effects, hold great promise to overcome the observed drug resistance. Currently, multifaceted investigations are probing the resistance mechanisms associated with clinical drugs, and identifying new breast cancer-associated molecular targets that may lead to improved therapeutic approaches with the nanoparticle platforms. Nanoparticle platforms including siRNA, antibody-specific targeting and the role of nanoparticles in cellular processes and their effect on breast cancer were discussed in this article.

Keywords: Breast cancer; Drug resistance; Therapeutic targets/delivery (new discoveries).

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References

    1. Abdullah LN, Chow EK-H (2013) Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med 2:3 - PubMed - PMC
    1. Ajabnoor GMA, Crook T, Coley HM (2012) Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells. Cell Death Dis 3:e260–e260 - PubMed - PMC
    1. Akbal Ö, Erdal E, Vural T, Kavaz D, Denkbaş EB (2017) Comparison of protein- and polysaccharide-based nanoparticles for cancer therapy: synthesis, characterization, drug release, and interaction with a breast cancer cell line. Artif Cells Nanomed Biotechnol 45:193–203 - PubMed
    1. Albrecht MA, Evans CW, Raston CL (2006) Green chemistry and the health implications of nanoparticles. Green Chem 8:417–432
    1. Ali S, Rasool M, Chaoudhry HPNP, Jha P, Hafiz A, Mahfooz M, Abdus Sami G, Azhar Kamal M, Bashir S, Ali A, Sarwar Jamal M (2016) Molecular mechanisms and mode of tamoxifen resistance in breast cancer. Bioinformation 12:135–139 - PubMed - PMC

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