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. 2021 Dec;13(12):1015-1024.
doi: 10.1111/1753-0407.13216. Epub 2021 Jul 29.

Combined association of skeletal muscle mass and grip strength with cardiovascular diseases in patients with type 2 diabetes

Sunmin Park  1 , Sung-Hoon Kim  2 , Jang Yel Shin  3
Affiliations

Combined association of skeletal muscle mass and grip strength with cardiovascular diseases in patients with type 2 diabetes

Sunmin Park et al. J Diabetes. 2021 Dec.

Abstract
in English, Chinese

Background: Appendicular skeletal muscle mass (ASM) and grip strength (GS) have been suggested to be related to cardiovascular diseases (CVDs), but their association with type 2 diabetes (T2D) remains unclear. Therefore, we examined the combined association of ASM and GS with the prevalence of CVD in patients with T2D.

Methods: A total of 1230 patients with T2D were recruited and divided into four groups based on the sex-specific median values of ASM adjusted for body mass index (ASM/BMI; short: SM) and GS: high SM/high GS (HSM/HGS), high SM/low GS (HSM/LGS), low SM/high GS (LSM/HGS), and low SM/low GS (LSM/LGS).

Results: The LSM/LGS group was older and had higher values of systolic blood pressure, homeostasis model assessment of insulin resistance, waist circumference, and C-reactive protein but lower high-density lipoprotein cholesterol concentrations than the HSM/HGS group. After adjusting for potential confounders, the odds ratios (ORs) and 95% CIs for CVD, coronary heart disease (CHD), ischemic stroke, and peripheral arterial disease (PAD) in the LSM/LGS group were 2.90 (1.89-4.47), 2.39 (1.46-3.92), 1.77 (0.84-3.71), and 5.83 (1.58-21.48), respectively. After adjusting for variable confounders among patients with higher glycosylated hemoglobin (HbA1c) (≥7.1%), the ORs and 95% CIs for CVD and CHD in the LSM/LGS group were 7.27 (3.37-15.67) and 6.17 (2.65-14.37), respectively.

Conclusions: The combination of low SM and GS was strongly associated with CVD, CHD, and PAD in patients with T2D, especially in those with higher HbA1c levels.

背景: 四肢骨骼肌质量(ASM)和握力(GS)已被认为与心血管疾病(CVD)有关, 但它们与2型糖尿病(T2D)的关系尚不清楚。因此, 我们研究了ASM和GS与T2D患者心血管疾病患病率的联合关系。 方法: 将1230例T2D患者根据体重指数(BMI)和GS校正后的ASM性别中值分为4组:高SM/高GS组(HSM/HGS)、高SM/低GS组(HSM/LGS)、低SM/高GS组(LSM/HGS)、低SM/低GS组(LSM/LGS)。 结果: 与HSM/HGS组相比, LSM/LGS组年龄更大, 收缩压、胰岛素抵抗的稳态、腰围和C反应蛋白水平更高, 而高密度脂蛋白胆固醇浓度更低。调整潜在混杂因素后, LSM/LGS组心血管疾病、冠心病、缺血性卒中和外周动脉疾病的OR值和95%CI分别为2.90(1.89~4.47)、2.39(1.46~3.92)、1.77(0.84~3.71)和5.83(1.58~21.48)。调整高糖化血红蛋白(≥7.1%)患者的变量混杂因素后, LSM/LGS组心血管疾病和冠心病的OR值和95%CI分别为7.2 7(3.37~15.6 7)和6.17(2.6 5~14.37)。 结论: 在T2D患者中, 低SM和GS的组合与CVD、CHD和PAD密切相关, 尤其是在HbA1c水平较高的患者。.

Keywords: 2型糖尿病; HbA1C; appendicular skeletal muscle mass; cardiovascular disease; grip strength; type 2 diabetes; 四肢骨骼肌质量; 心血管疾病; 握力; 糖化血红蛋白.

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References

REFERENCES

    1. Severinsen MCK, Pedersen BK. Muscle-organ crosstalk: the emerging roles of myokines. Endocr Rev. 2020;41(4):594-609.
    1. Luo D, Lin Z, Li S, Liu SJ. Effect of nutritional supplement combined with exercise intervention on sarcopenia in the elderly: a meta-analysis. Int J Nurs Sci. 2017;4:389-401.
    1. Kim TN, Park MS, Yang SJ, et al. Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care. 2010;33:1497-1499.
    1. Murata Y, Kadoya Y, Yamada S, Sanke T. Sarcopenia in elderly patients with type 2 diabetes mellitus: prevalence and related clinical factors. Diabetol Int. 2018;9:136-142.
    1. Anagnostis P, Gkekas NK, Achilla C, et al. Type 2 diabetes mellitus is associated with increased risk of sarcopenia: a systematic review and meta-analysis. Calcif Tissue Int. 2020;107:453-463.