Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul:43 Suppl 1:23-28.
doi: 10.1111/ijlh.13536.

Cytomorphology of normal, reactive, dysmorphic, and dysplastic megakaryocytes in bone marrow aspirates

Gina Zini  1   2 , Marcello Viscovo  1
Affiliations
Review

Cytomorphology of normal, reactive, dysmorphic, and dysplastic megakaryocytes in bone marrow aspirates

Gina Zini et al. Int J Lab Hematol. 2021 Jul.

Abstract

This paper aims to emphasize the importance of applying international consensus guidelines to detect qualitative and quantitative abnormalities of megakaryocytes on smears of bone marrow aspirates (BMA) for a shared and harmonized diagnostic path between different laboratories. Careful evaluation of megakaryocytes on BMA smears represents a cornerstone in the diagnosis of most clonal and nonclonal hematological diseases. Images associated with the detailed morphologic description of normal, reactive, abnormal, and dysplastic megakaryocytes are also reported together with examples of similar cells that, if not promptly identified, can lead to a morphological misdiagnosis.

Keywords: WHO Classification; bone marrow; megakaryocyte; morphology; myelodysplasia; myeloproliferative neoplasms.

PubMed Disclaimer

References

REFERENCES

    1. Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005;115:3339-3347.
    1. Hesseldahl H, Falck LJ. Hemopoiesis and blood vessels in human yolk sac. An electron microscopic study. Acta Anat. 1971;78:274-294.
    1. Hartwig J, Italiano J Jr. The birth of the platelet. J Thromb Haemost. 2003;1:1580-1586.
    1. Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Front Biosci. 2007;12:2050-2062.
    1. Gorelashvili MG, Angay O, Hemmen K, Klaus V, Stegner D, Heinze KG. Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics. Haematologica. 2020;105:895-904.

LinkOut - more resources