Omani experience with the use of factor IX Fc fusion protein
- PMID: 34290003
- PMCID: PMC8296795
- DOI: 10.1136/bcr-2020-241154
Omani experience with the use of factor IX Fc fusion protein
Abstract
We describe our local experience in the management of haemophilia B patients with factor IX Fc fusion protein. Two children with haemophilia B were managed with the use of a personalised/tailored dosing schedule of factor IX Fc fusion protein. Compared with the standard half-life factor IX, prophylaxis with factor IX Fc fusion protein was cost-effective, with much less injections, better bleeding control, improved tolerability or no inhibitor development.
Keywords: congenital disorders; haematology (incl blood transfusion); paediatrics.
© BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Conflict of interest statement
Competing interests: None declared.
Similar articles
-
Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B.Thromb Haemost. 2017 Feb 28;117(3):508-518. doi: 10.1160/TH16-05-0398. Epub 2016 Dec 22. Thromb Haemost. 2017. PMID: 28004057 Clinical Trial.
-
Surgical outcomes in patients with haemophilia A or B receiving extended half-life recombinant factor VIII and IX Fc fusion proteins: Real-world experience in the Nordic countries.Haemophilia. 2022 Sep;28(5):713-719. doi: 10.1111/hae.14585. Epub 2022 May 16. Haemophilia. 2022. PMID: 35575446 Free PMC article.
-
Clinical use of recombinant factor VIII Fc and recombinant factor IX Fc in patients with haemophilia A and B.Haemophilia. 2018 May;24(3):414-419. doi: 10.1111/hae.13432. Epub 2018 Feb 5. Haemophilia. 2018. PMID: 29405496
-
Role of enhanced half-life factor VIII and IX in the treatment of haemophilia.Br J Haematol. 2015 Jun;169(6):768-76. doi: 10.1111/bjh.13360. Epub 2015 Mar 7. Br J Haematol. 2015. PMID: 25754016 Review.
-
Continuous prophylaxis with recombinant factor IX Fc fusion protein and conventional recombinant factor IX products: comparisons of efficacy and weekly factor consumption.J Med Econ. 2017 Apr;20(4):337-344. doi: 10.1080/13696998.2016.1265973. Epub 2016 Dec 21. J Med Econ. 2017. PMID: 27885871
References
-
- National Hemophila Foundation . Bleeding disorder, types of bleeding disorder (hemophilia B), 2019. Available: https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorder...
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources