Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep;22(9):553-572.
doi: 10.1038/s41583-021-00488-y. Epub 2021 Jul 21.

Brain vulnerability and viability after ischaemia

Stefano G Daniele  1   2   3 , Georg Trummer  4 , Konstantin A Hossmann  5 , Zvonimir Vrselja  1   2 , Christoph Benk  4 , Kevin T Gobeske  6 , Domagoj Damjanovic  4 , David Andrijevic  1   2 , Jan-Steffen Pooth  4 , David Dellal  7 , Friedhelm Beyersdorf  8 , Nenad Sestan  9   10   11   12   13   14   15
Affiliations
Review

Brain vulnerability and viability after ischaemia

Stefano G Daniele et al. Nat Rev Neurosci. 2021 Sep.

Abstract

The susceptibility of the brain to ischaemic injury dramatically limits its viability following interruptions in blood flow. However, data from studies of dissociated cells, tissue specimens, isolated organs and whole bodies have brought into question the temporal limits within which the brain is capable of tolerating prolonged circulatory arrest. This Review assesses cell type-specific mechanisms of global cerebral ischaemia, and examines the circumstances in which the brain exhibits heightened resilience to injury. We suggest strategies for expanding such discoveries to fuel translational research into novel cytoprotective therapies, and describe emerging technologies and experimental concepts. By doing so, we propose a new multimodal framework to investigate brain resuscitation following extended periods of circulatory arrest.

PubMed Disclaimer

References

    1. Lowry, O. H., Passonneau, J. V., Hasselberger, F. X. & Schulz, D. W. Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J. Biol. Chem. 239, 18–30 (1964). This is one of the first seminal articles describing the effects of global ischaemia on metabolic compounds in the brain using the decapitation model. - PubMed - DOI
    1. Virani, S. S. et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation 141, e139–e596 (2020). - PubMed - DOI
    1. Weisfeldt, M. L. & Becker, L. B. Resuscitation after cardiac arrest: a 3-phase time-sensitive model. JAMA 288, 3035–3038 (2002). - PubMed - DOI
    1. Moulaert, V. R., Verbunt, J. A., van Heugten, C. M. & Wade, D. T. Cognitive impairments in survivors of out-of-hospital cardiac arrest: a systematic review. Resuscitation 80, 297–305 (2009). - PubMed - DOI
    1. Wagner, S. R. T. & Lanier, W. L. Metabolism of glucose, glycogen, and high-energy phosphates during complete cerebral ischemia. A comparison of normoglycemic, chronically hyperglycemic diabetic, and acutely hyperglycemic nondiabetic rats. Anesthesiology 81, 1516–1526 (1994). - PubMed - DOI

LinkOut - more resources