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. 2021 Sep;23(9):1767-1775.
doi: 10.1111/jch.14268. Epub 2021 Jul 22.

Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case-control study

IfeanyiChukwu O Onor  1   2   3 , Rose M Duchane  1 , Casey J Payne  1 , Hannah Naquin Lambert  1 , DeMaurian M Mitchner  1   3 , Robbie A Beyl  4 , Anh T Nguyen  1 , Sarah E Bilbe  1 , Andrea Arriaga White  1 , Mariah W Johnson  1 , Amber I Faciane  1 , Emmanuel Kouagou  1 , Stephanie A Hymel  1 , Bria M Wates  1 , Asia D Sanders  1 , Phillip C B Vo  1 , Jordan D Bates  1 , Raven J Spooner  1 , Christopher J Gillard  1   2   3 , John I Okogbaa  1   2 , Daniel F Sarpong  1   5 , Rim M Hadgu  6 , Samuel C Okpechi  7 , Gabriel I Onor Jr  8 , Michael C Okoronkwo  2 , Mihran V Naljayan  2 , Shane G Guillory  2 , Shane E Sanne  2 ; CardioRenal Research Group (CRRG)
Affiliations

Evaluation of serum calcium differences in hypertensive crises and control patients: A randomly matched case-control study

IfeanyiChukwu O Onor et al. J Clin Hypertens (Greenwich). 2021 Sep.

Abstract

The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age-, sex-, race-, diabetes, and body mass index matched). This study is a single-center, retrospective, chart review, case-control study of patients with hypertensive crises (case group) and patients without hypertensive crises (control group). Patients were included in the case group if they were 18 years of age or older with hypertensive crises and have a documented calcium level. The control group patients were required to be 18 years of age or older, have a documented calcium level, and have no diagnosis of hypertensive crises. The primary outcome of the study was to compare the mean serum calcium in patients with hypertensive crises vs patients without hypertensive crises. Five hundred and sixty-six patients were included in the study: 283 patients in both the case group and control group. The primary outcome results showed that serum calcium concentration was not significantly different between the case group (8.99 ± 0.78 mg/dL) and control group (8.96 ± 0.75 mg/dL) (P = .606). This study found no significant difference in serum calcium levels in patients with hypertensive crises compared to a random matched control group. Larger observational or experimental studies may be useful to evaluate the effect of calcium on blood pressure in hypertensive crises.

Keywords: calcium; hypertension-general; hypertensive crises; magnesium; phosphorus.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Flow chart of patient selection into the case group and random matched control group
See this image and copyright information in PMC

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