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. 1987 Dec;8(6):589-92.
doi: 10.1007/BF02333666.

Short-term intensive cyclophosphamide treatment in progressive multiple sclerosis

G F Siracusa  1 , M P Amato, L Fratiglioni, D Sità, L Amaducci
Affiliations

Short-term intensive cyclophosphamide treatment in progressive multiple sclerosis

G F Siracusa et al. Ital J Neurol Sci. 1987 Dec.

Abstract

14 patients with chronic progressive multiple sclerosis, selected in a preliminary uncontrolled trial, were given a short course of intensive cyclophosphamide therapy, which was discontinued when the leukocyte count fell to 3000 cu.mm. 5 patients dropped out because of severe side effects. At 1 year follow-up were neurologically unchanged since admission to the trial; 4 remained stable at 2 years. The lack of clinical improvement, the high frequency of side effects and the proven oncogenicity of cyclophosphamide led us to discontinue the trial.

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