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Comparative Study
. 2021 Dec 1;41(12):2479-2484.
doi: 10.1097/IAE.0000000000003266.

SALIVARY ALPHA-AMYLASE LEVELS MAY CORRELATE WITH CENTRAL SEROUS CHORIORETINOPATHY ACTIVITY

Paula Scholz  1 , Lebriz Altay  1 , Vasilena Sitnilska  1 , Elon H C van Dijk  2 , Alberto M Pereira  3 , Femke M van Haalen  3 , Isha Akhtar  4 , Camiel J F Boon  2   5 , Sascha Fauser  1   6
Affiliations
Comparative Study

SALIVARY ALPHA-AMYLASE LEVELS MAY CORRELATE WITH CENTRAL SEROUS CHORIORETINOPATHY ACTIVITY

Paula Scholz et al. Retina. .

Abstract

Purpose: To investigate and compare the salivary alpha-amylase (sAA) activity as an indicator of the sympathetic activity and stress response in patients with central serous chorioretinopathy (CSC) and healthy control subjects.

Methods: Prospective multicenter case series, including 80 CSC patients and 88 healthy control subjects. Central serous chorioretinopathy status was classified as either active or inactive, depending on the presence of subretinal fluid on optical coherence tomography. Salivary samples were collected in the morning from patients and control subjects of the main cohort and at midnight for the additional cohort. Salivary alpha-amylase activity was determined in all patients and control subjects.

Results: Morning sAA activity was significantly higher in patients with active CSC compared with inactive CSC (P = 0.049) and to healthy control subjects (P = 0.012). There was no significant difference in sAA activity between patients with inactive CSC and control subjects (P = 1.0). Nocturnal sAA activity did not show any significant difference between patients with active CSC and either inactive CSC or control subjects (P = 0.139).

Conclusion: Morning sAA activity is increased in patients with active CSC, although diurnal rhythmicity is preserved. Measurement of sAA is easy to perform and might be an eligible tool to further investigate the relation between stress and CSC.

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Comment in

  • Salivary Alpha-Amylase Levels May Correlate With Central Serous Chorioretinopathy Activity.
    Abdelhakim AH, Ledesma-Gil G, Yannuzzi LA. Abdelhakim AH, et al. Retina. 2021 Oct 1;41(10):2007-2008. doi: 10.1097/IAE.0000000000003265. Retina. 2021. PMID: 34292223 No abstract available.
  • Reply.
    Scholz P, Altay L, Sitnilska V, van Dijk EHC, Pereira AM, van Haalen FM, Akhtar I, Boon CJF, Fauser S. Scholz P, et al. Retina. 2022 Oct 1;42(10):e50-e51. doi: 10.1097/IAE.0000000000003575. Retina. 2022. PMID: 35921625 No abstract available.

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