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Editorial
. 2021 Jul 23;129(3):414-416.
doi: 10.1161/CIRCRESAHA.121.319642. Epub 2021 Jul 22.

Epigenetic Regulation of Heart Failure: Cell Type Matters

Stephanie L Padula  1 , Katherine E Yutzey  1
Affiliations
Editorial

Epigenetic Regulation of Heart Failure: Cell Type Matters

Stephanie L Padula et al. Circ Res. .
No abstract available

Keywords: Editorials; extracellular matrix; fibrosis; heart failure; histones; methylation.

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Figures

Figure.
Figure.. Cell type-specific epigenetic mechanisms in fibroblasts and cardiomyocytes after cardiac injury.
Lysine-specific histone demethylase-1 (LSD1) inhibition has differential effects on fibroblasts and cardiomyocytes. The loss of LSD1 in Postn+ fibroblasts after transverse aortic constriction (TAC) reduces fibrosis, cardiomyocyte (CM) hypertrophy, extracellular matrix (ECM) deposition, and TGFβ activity, that also blunts CM hypertrophy. In contrast, the loss of LSD1 in cardiomyocytes leads to hypertrophy and fibrosis in the absence of injury, with increased cardiac pathology after TAC.
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Comment on

References

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