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Editorial
. 2021 Jul 23;129(3):417-419.
doi: 10.1161/CIRCRESAHA.121.319651. Epub 2021 Jul 22.

RyR2 Gain-of-Function and Not So Sudden Cardiac Death

Shanna Hamilton  1 , Dmitry Terentyev  1
Affiliations
Editorial

RyR2 Gain-of-Function and Not So Sudden Cardiac Death

Shanna Hamilton et al. Circ Res. .
No abstract available

Keywords: Editorials; cardiac arrhythmias; ryanodine receptor calcium release channel; sarcoplasmic reticulum.

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Figures

Figure 1
Figure 1. Schematic demonstrating the mechanisms of dysfunction caused by CPVT-associated mutation RyR2R420Q.
R420Q mutation causes tighter RyR2 interdomain interaction, SR expansion and derangement of LTCC-RyR2 coupling due to the loss of RyR2 association with JPH2. Created with Biorender.com.
See this image and copyright information in PMC

Comment on

  • Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation.
    Yin L, Zahradnikova A Jr, Rizzetto R, Boncompagni S, Rabesahala de Meritens C, Zhang Y, Joanne P, Marqués-Sulé E, Aguilar-Sánchez Y, Fernández-Tenorio M, Villejoubert O, Li L, Wang YY, Mateo P, Nicolas V, Gerbaud P, Lai FA, Perrier R, Álvarez JL, Niggli E, Valdivia HH, Valdivia CR, Ramos-Franco J, Zorio E, Zissimopoulos S, Protasi F, Benitah JP, Gómez AM. Yin L, et al. Circ Res. 2021 Jul 23;129(3):e35-e52. doi: 10.1161/CIRCRESAHA.121.319094. Epub 2021 Jun 11. Circ Res. 2021. PMID: 34111951 Free PMC article.

References

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