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. 2022 Apr 9;74(7):1268-1270.
doi: 10.1093/cid/ciab648.

The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living With Human Immunodeficiency Virus (HIV)

Bezawit A Woldemeskel  1 , Andrew H Karaba  1 , Caroline C Garliss  1 , Evan J Beck  2 , Kristy H Wang  1 , Oliver Laeyendecker  2 , Andrea L Cox  1 , Joel N Blankson  1
Affiliations

The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living With Human Immunodeficiency Virus (HIV)

Bezawit A Woldemeskel et al. Clin Infect Dis. .

Abstract

Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.

Keywords: COVID; PLWH; SARS-CoV-2; mRNA vaccine.

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Figures

Figure 1.
Figure 1.
Titer of SARS-CoV-2 spike binding antibodies from HD and PLWH (A). The horizontal line represents the 90th percentile titer in patients with natural infection. Titer of neutralizing antibodies to spike proteins from vaccine strains SARS-CoV2 (B) and variants of concern (C–F). SFUs (G) and SIs (H) to SARS-CoV-2 spike peptide pools from PBMCs from vaccinated PLWH. Black horizontal bars represent the median value for PLWH. Dashed red horizontal bar represents the median value for vaccinated HD from a prior study [7]. Dashed black horizontal lines denote a significant response (SFU > 20 and SI > 3). Breadth of CD8-depleted T-cell responses from PLWH to pools of 10 peptides that sequentially cover the entire spike protein (E). Horizontal bars represent the median values for PLWH; red horizontal line represents the HD median value. Abbreviations: HD, healthy donors; PBMC, peripheral blood mononuclear cells; PLWH, people living with human immunodeficiency virus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SFU, spot-forming units; SI, stimulation index.
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