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Comment
. 2021 Jul 21;109(14):2203-2204.
doi: 10.1016/j.neuron.2021.06.031.

Of mice and men: What a mouse model of microglial C9ORF72 deficiency does-and does not-tell us about human neurodegenerative diseases

Alice S Chen-Plotkin  1
Affiliations
Comment

Of mice and men: What a mouse model of microglial C9ORF72 deficiency does-and does not-tell us about human neurodegenerative diseases

Alice S Chen-Plotkin. Neuron. .

Abstract

Expansions in C9ORF72, which cause frontotemporal dementia and amyotrophic lateral sclerosis, result in formation of aberrant peptide and RNA species and decreased expression of the normal gene. In this issue of Neuron, Lall et al. (2021) report the consequences of microglial C9ORF72 deficiency in mouse models of aging and Alzheimer's disease.

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References

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