Replenishing our mind orchards: Enhancing myelin renewal to rescue cognition in Alzheimer's disease
- PMID: 34293288
- DOI: 10.1016/j.neuron.2021.06.024
Replenishing our mind orchards: Enhancing myelin renewal to rescue cognition in Alzheimer's disease
Abstract
In this issue of Neuron, Chen et al. (2021) reveal dynamic changes in myelin in an Alzheimer's disease (AD) mouse model. Enhancing myelination genetically or pharmacologically improves cognition in this model, supporting myelin as a therapeutic target for AD.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests V.E.M. has received consultancy funds from Novartis and Biogen and research funds from Biogen, Clene Nanomedicine, ReWind Therapeutics, and GSK.
Comment on
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Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer's disease.Neuron. 2021 Jul 21;109(14):2292-2307.e5. doi: 10.1016/j.neuron.2021.05.012. Epub 2021 Jun 7. Neuron. 2021. PMID: 34102111 Free PMC article.
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