Digestive tract reconstruction of laparoscopic total gastrectomy for gastric cancer: a comparison of the intracorporeal overlap, intracorporeal hand-sewn anastomosis, and extracorporeal anastomosis

Abstract

Background: The application of esophagojejunostomy has certain difficulties in totally laparoscopic total gastrectomy (TLTG). This is due to the higher requirement for surgical techniques and the lack of any unified standards. This study aim to explore the practicability and safety of intracorporeal overlap and intracorporeal hand-sewn anastomosis compared with extracorporeal anastomosis.

Methods: The clinical pathological data of 56 patients who underwent TLTG from March 2016 to December 2020 in the Harbin Medical University Cancer Hospital were retrospectively analyzed. According to the method of anastomosis, the patients were divided into the overlap (n=36) and the hand-sewn anastomosis (n=20). Patients who receive laparoscopic-assisted total gastrectomy (LATG; n=74) formed the control group. The basic clinical data, and intraoperative and postoperative results of the patients were assessed.

Results: Compared with the control group, the overlap anastomosis and hand-sewn anastomosis groups showed no significant differences in clinicopathological data and short-term postoperative recovery. There were no significant differences between the overlap and the control group in operation time nor anastomosis time. However, the anastomosis time of the hand-sewn anastomosis group was significantly prolonged compared to the control group (53.20±14.14 vs. 43.01±12.53 minutes, P=0.002). Compared with the control group, the operation cost was significantly higher in the overlap group (CNY 81,300±6,100 vs. CNY 76,600±6,800, P=0.001), but significantly lower in the hand-sewn anastomosis group (CNY 71,900±1,700 vs. CNY 76,600±6,800, P=0.003). Early postoperative complications occurred in 5 cases (13.9%) in the overlap group, 3 cases (15.0%) in the hand-sewn anastomosis group, and 11 cases (14.9%) in the control group. There were 3 cases (8.3%) of postoperative anastomotic-related complications in the overlap group. No anastomotic-related complications were observed in the hand-sewn anastomosis group.

Conclusions: The overlap anastomosis and hand-sewn anastomosis are practical and safe. Furthermore, the overlap anastomosis may be more suitable for patients with lower cardia and fundic lesions. The hand-sewn method has a wider range of indications pending advanced surgical skills, and is an effective supplementary technique for instrument anastomosis.

Keywords: Gastric cancer; circular stapler; hand-sewn; linear stapler; overlap; totally laparoscopic total gastrectomy (TLTG).

Figure 1

Location and distribution of trocars.

Figure 2

Overlap anastomosis. (A) A small incision was made in the center of the distal esophageal stump and the dorsal wall of mesentery. (B) The anterior wall of esophagus was anastomosed with the posterior wall of jejunum. (C) The common opening was closed by hand-sewn anastomosis.

Figure 3

Hand-sewn anastomosis. (A) Continuous suture along the posterior wall of the esophageal stump and the posterior wall of the jejunum. Matching incisions were made. (B) Continuous suture of the posterior wall of the anastomosis. (C) Continuous suture of the anterior wall of the anastomosis.

Figure 4

The distance from the upper edge of the tumor to the cutting edge of the esophagus in the overlap group was shorter than that in the hand-sewn anastomosis group and the control group. *, P<0.05.