Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 12;8(7):ofab312.
doi: 10.1093/ofid/ofab312. eCollection 2021 Jul.

Time Course of Neutralizing Antibody in Health Care Workers With Mild or Asymptomatic COVID-19 Infection

Ilaria Vicenti  1 , Francesca Gatti  2 , Renzo Scaggiante  3 , Adele Boccuto  1 , Eliana Modolo  3 , Daniela Zago  2 , Monica Basso  2 , Filippo Dragoni  1 , Niccolo' Bartolini  1 , Maurizio Zazzi  1 , Saverio Giuseppe Parisi  2
Affiliations

Time Course of Neutralizing Antibody in Health Care Workers With Mild or Asymptomatic COVID-19 Infection

Ilaria Vicenti et al. Open Forum Infect Dis. .

Abstract

We describe the time course of neutralizing antibody (NtAb) titer in a cohort of health care workers with mild or asymptomatic severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. NtAb levels decreased over time; however, serum neutralizing activity remained detectable after a median of 7 months from SARS-CoV-2 diagnosis in the majority of cases.

Keywords: SARS-CoV-2; follow-up; health care workers; mild or asymptomatic infection; neutralizing antibody titer.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Dynamics of NtAb titers in the 42 subjects with asymptomatic infection and the 25 subjects with mild symptomatic infection, measured at 2 different time points following SARS-CoV-2 diagnosis. Each line represents 1 subject. Abbreviations: EC50, half maximal serum neutralization titer; NtAb, neutralizing antibody; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; T1, first NtAb titration; T2, interval between diagnosis and the second titration.
See this image and copyright information in PMC

References

    1. Mussini C, Falcone M, Nozza S, et al. ; Italian Society of Infectious and Tropical Diseases . Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT). Clin Microbiol Infect 2021; 27:389–95. - PMC - PubMed
    1. National Institutes of Health. COVID-19 treatment guidelines. Available at: https://www.covid19treatmentguidelines.nih.gov/. Accessed 6 March 2021. - PubMed
    1. Huang AT, Garcia-Carreras B, Hitchings MDT, et al. . A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity. Nat Commun 2020; 11:4704. - PMC - PubMed
    1. Zinkernagel RM. On natural and artificial vaccinations. Annu Rev Immunol 2003; 21:515–46. - PubMed
    1. World Health Organization. Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-nCoV) Infection Is Suspected: Interim Guidance. Geneva: World Health Organization; 2020.