Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;259(12):3757-3767.
doi: 10.1007/s00417-021-05291-0. Epub 2021 Jul 23.

Long-term prognosis for glaucoma in patients with Posner-Schlossman syndrome

Jin-Ho Kim #  1 , Ji-Young Lee #  1 , Jin A Choi  2
Affiliations

Long-term prognosis for glaucoma in patients with Posner-Schlossman syndrome

Jin-Ho Kim et al. Graefes Arch Clin Exp Ophthalmol. 2021 Dec.

Abstract

Background: The aim of this study is to investigate the long-term prognosis for glaucoma in patients with Posner-Schlossman syndrome (PSS).

Methods: In this retrospective case series study, a total of 98 patients with PSS from January 2014 to February 2019 were included in this study. Initial presentations and follow-up data were obtained from medical records. Vision-related quality of life (VR-QoL) was assessed using the 25-item National Eye Institute Visual Functioning Questionnaire.

Results: Of the 98 patients included in the study, 66 (67%) presented with glaucoma, and among them, 21 (32%) required glaucoma surgery. The mean follow-up time was 50.1 months (range 1-263 months). Iris involvement was noted in 46 (46.9%) eyes; 26 (26.5%) had sectoral iris changes and 20 (20.4%) showed diffuse iris changes. Eyes with iris involvement had a significantly higher number of acute attacks of uveitis than those without (p = 0.010). The 5-year glaucoma surgery-free interval was 77.8% according to Kaplan-Meier analysis. Significant predictors of glaucoma surgery included iris involvement (hazard ratio [HR] = 5.215; confidence interval [CI] = 1.387-19.610), highest number of anti-glaucoma agents (HR = 5.069; CI = 1.848-13.905), baseline average retinal nerve fiber layer thickness (RNFLT) thickness (HR = 0.949; CI = 0.917-0.982), and disease duration (HR = 0.977; CI = 0.957-0.996). Overall complete surgical success and qualified success at 2 years was 35.3% and 75.5%, respectively. Patients with iris involvement, glaucoma surgery, and thinner average RNFLT had significantly poorer VR-QoL (all, p < 0.05).

Conclusions: Patients with PSS and glaucoma required glaucoma surgery in a high rate. Iris involvement increased the probability of surgical treatment and lowered the VR-QoL of PSS patients.

Keywords: Glaucoma surgery; Posner–Schlossman syndrome; Uveitis; Vision-related quality of life.

PubMed Disclaimer

References

    1. Acharya NR, Tham VM, Esterberg E, Borkar DS, Parker JV, Vinoya AC, Uchida A (2013) Incidence and prevalence of uveitis: results from the Pacific Ocular Inflammation Study. JAMA Ophthalmol 131:1405–1412. https://doi.org/10.1001/jamaophthalmol.2013.4237 - DOI - PubMed
    1. Takase H, Kubono R, Terada Y, Imai A, Fukuda S, Tomita M, Miyanaga M, Kamoi K, Sugita S, Miyata K, Mochizuki M (2014) Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Jpn J Ophthalmol 58:473–482. https://doi.org/10.1007/s10384-014-0340-6 - DOI - PubMed
    1. Megaw R, Agarwal PK (2017) Posner-Schlossman syndrome. Surv Ophthalmol 62:277–285. https://doi.org/10.1016/j.survophthal.2016.12.005 - DOI - PubMed
    1. Chan NS, Chee SP (2019) Demystifying viral anterior uveitis: a review. Clin Exp Ophthalmol 47:320–333. https://doi.org/10.1111/ceo.13417 - DOI - PubMed
    1. Kandori M, Miyazaki D, Yakura K, Komatsu N, Touge C, Ishikura R, Inoue Y (2013) Relationship between the number of cytomegalovirus in anterior chamber and severity of anterior segment inflammation. Jpn J Ophthalmol 57:497–502. https://doi.org/10.1007/s10384-013-0268-2 - DOI - PubMed

LinkOut - more resources