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Observational Study
. 2022 Feb;53(2):417-424.
doi: 10.1007/s11239-021-02512-5. Epub 2021 Jul 22.

Effectiveness of a multidisciplinary care program for the management of venous thromboembolism in cancer patients: a pilot study

Ilham Benzidia  1 , Benjamin Crichi  1 , Claire Montlahuc  2 , Hanadi Rafii  3 , Arlette N'Dour  1 , Maxime Sebuhyan  1 , Hélène Gauthier  4 , Nassim Ait Abdallah  1 , Philippe Benillouche  5 , Stéphane Villiers  6 , Christine Le Maignan  4 , Dominique Farge  7   8   9
Affiliations
Observational Study

Effectiveness of a multidisciplinary care program for the management of venous thromboembolism in cancer patients: a pilot study

Ilham Benzidia et al. J Thromb Thrombolysis. 2022 Feb.

Abstract

Introduction: Treatment of Venous thromboembolism (VTE) in cancer patients is challenging due to higher risk of VTE recurrence or bleeding under anticoagulants. We assessed the effectiveness of a dedicated "Allo-Thrombosis Cancer" multidisciplinary care program (AlloTC-MCP) that incorporated individualized care, regular follow-ups, telephone counselling, and a patient education program.

Methods and materials: From September 2017 to October 2019, 100 consecutive cancer patients with new VTE onset were enrolled in this observational single-center prospective pilot study and received standard (control group, n = first 50 patients enrolled) or AlloTC-MCP care (n = next 50 patients enrolled) over a 6-month VTE treatment follow-up period. Primary end-point was the percentage of adherence to the International Clinical Practice Guidelines (ITAC-CPGs) at 6 (M6) month follow-up.

Results: Among the 100 patients with different cancer types (22% genitourinary, 19% breast, 16% gastrointestinal, 15% lymphoma, 11% lung and 17% others), 51 patients (61%) had metastatic disease and 31 (31%) received chemotherapy alone. Main baseline cancer and VTE clinical characteristics did not differ between the 2 groups. Adherence rates to ITAC-CPGs was significantly higher in the AlloTC-MCP group (100% (M0), 72% (M3) and 68% (M6)) compared with the control group (84% (M0), 8% (M3) and 16% (M6)). Quality of Life (QoL) was significantly improved in the AlloTC-MCP group 6 months after inclusion.

Conclusion: The "AlloTC-MCP" was associated with improved adherence to ITAC-CPGs and merits further expansion.

Keywords: Anticoagulant; Cancer; Clinical practice guidelines; Multidisciplinary care program; Quality of life; Venous thromboembolism.

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References

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