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Comment
. 2021 Aug;194(4):659-660.
doi: 10.1111/bjh.17528. Epub 2021 Jul 22.

Chimeric antigen receptor T-cell toxicities - using steroids to spare steroids?

Andrea Kuhnl  1
Affiliations
Comment

Chimeric antigen receptor T-cell toxicities - using steroids to spare steroids?

Andrea Kuhnl. Br J Haematol. 2021 Aug.
No abstract available

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Comment on

  • Prophylactic corticosteroid use in patients receiving axicabtagene ciloleucel for large B-cell lymphoma.
    Oluwole OO, Bouabdallah K, Muñoz J, De Guibert S, Vose JM, Bartlett NL, Lin Y, Deol A, McSweeney PA, Goy AH, Kersten MJ, Jacobson CA, Farooq U, Minnema MC, Thieblemont C, Timmerman JM, Stiff P, Avivi I, Tzachanis D, Kim JJ, Bashir Z, McLeroy J, Zheng Y, Rossi JM, Johnson L, Goyal L, van Meerten T. Oluwole OO, et al. Br J Haematol. 2021 Aug;194(4):690-700. doi: 10.1111/bjh.17527. Epub 2021 Jul 22. Br J Haematol. 2021. PMID: 34296427 Free PMC article. Clinical Trial.

References

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    1. Nastoupil LJ, Jain MD, Feng L, Spiegel JY, Ghobadi A, Lin Y, et al. Standard-of-care axicabtagene ciloleucel for relapsed or refractory large B-cell lymphoma: results from the US lymphoma CAR T consortium. J Clin Oncol. 2020;38:3119-28.
    1. Jacobson CA, Hunter BD, Redd R, Rodig SJ, Chen PH, Wright K, et al. Axicabtagene ciloleucel in the non-trial setting: outcomes and correlates of response, resistance, and toxicity. J Clin Oncol. 2020;38:3095-106.
    1. Strati P, Ahmed S, Furqan F, Fayad LE, Lee HJ, Iyer SP, et al. Prognostic impact of corticosteroids on efficacy of chimeric antigen receptor T-cell therapy in large B-cell lymphoma. Blood. 2021 [Online ahead of print]. https://doi.org/10.1182/blood.2020008865.
    1. Strati P, Tummala S, Nastoupil LJ, Westin JR, Fayad L, Ahmed S, et al. Clinical and radiological correlates of neurotoxicity after standard of care axicabtagene ciloleucel in patients with relapsed/refractory large B-cell lymphoma. Blood. 2019;134(Suppl):765.

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