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. 2022 Jan;32(1):e13008.
doi: 10.1111/bpa.13008. Epub 2021 Jul 23.

Myxoid glioneuronal tumor, PDGFRA p.K385L-mutant, arising in midbrain tectum with multifocal CSF dissemination

B K Kleinschmidt-DeMasters  1   2   3 , Jason Chiang  4 , Andrew M Donson  5 , Thomas Borges  6 , Ahmed Gilani  1
Affiliations

Myxoid glioneuronal tumor, PDGFRA p.K385L-mutant, arising in midbrain tectum with multifocal CSF dissemination

B K Kleinschmidt-DeMasters et al. Brain Pathol. 2022 Jan.

Abstract

This myxoid glioneuronal tumor, PDGFRA p.K385L-mutant, arose in the midbrain tectum rather than in the septum pellucidum, as in the previously-reported cases.

Keywords: DNA methylation; brainstem; glioneuronal; next generation sequencing; tumors.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

FIGURE 1
FIGURE 1
(A) Axial non‐contrast‐enhanced T2‐weighted MRI demonstrates the tectal plate origin (arrowhead) of the tumor. (B) Sagittal contrast‐enhanced T1‐weighted MRI proves the absence of corpus callosal or lateral ventricular involvement but highlights the enhancing component within the tectal tumor (arrowhead). (C) Coronal contrast‐enhanced T1‐weighted MRI shows the nodular posterior fossa spread (black arrowhead) as well as leptomeningeal enhancement within cerebellar folia (white arrowheads). (D) Sagittal contrast‐enhanced T1‐weighted MRI of cervical spine shows nodular enhancing masses over the dorsum of the cord (arrowheads). (E). Sagittal contrast‐enhanced T1‐weighted MRI of thoracic spine shows nodular enhancing masses over the dorsum of cord (arrowheads). (F) Axial post contrast T1‐weighted MRI shows nodular enhancement (arrowhead) involving the left L5 nerve roots. (G) Low power view of the small oligodendroglial‐like cells embedded in copious mucin (hematoxylin & eosin). (H) Tumor nuclei were diffusely immunoreactive for OLIG2 (IHC for OLIG2 with light hematoxylin counterstain). (I) Hemosiderin (arrowheads) and eosinophilic granular bodies (arrows) were focally identified (H&E)
See this image and copyright information in PMC

References

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