Associations between alcohol consumption and hepatic steatosis in the USA

Abstract

Despite being widely recognized as a common cause of fatty liver, the exact impact of alcohol consumption on hepatic steatosis in the general population is elusive. The recent National Health and Nutrition Examination Survey (NHANES) allowed us to examine this relationship among US adults. Herein, we extracted data on detailed alcohol consumption and controlled attenuation parameter (CAP) by FibroScan from 4509 participants in NHANES 2017-2018. Compared to metabolic risk factors such as diabetes and obesity, the association between alcohol consumption and CAP was less significant. In multivariable analysis, only those drinking 5-7 times per week showed significant increases in CAP scores. Although both frequency and quantity of drinking were positively associated with CAP score, only frequency remained significant after adjustment for quantity and binge drinking. These epidemiological observations suggested that the impact of alcohol on hepatic steatosis was much smaller than metabolic factors and dependent upon the frequency of drinking.

Keywords: CAP; FibroScan; alcoholic liver disease; hepatic steatosis.

Figure 1.. Relationships between CAP and patterns of alcohol consumption, BMI, and diabetes

Associations between CAP and patterns of alcohol consumption in the past year, BMI (every 5 points), diabetes. Coefficients calculated by multivariable regression also including age, age square, race, smoking history, and adjusted by sampling weights. Full regression results can be found in Supplementary Table 1.