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Meta-Analysis
. 2022 Jan;10(1):42-50.
doi: 10.1111/andr.13083. Epub 2021 Aug 2.

Clinical use of hyaluronic acid in andrology: A review

Alessandro Zucchi  1 , Fabrizio Ildefonso Scroppo  2 , Paolo Capogrosso  2 , Andrea Salonia  3 , Jacopo Duante  1 , Vittorio Bini  4 , Giovanni Liguori  5 , Riccardo Bartoletti  1
Affiliations
Meta-Analysis

Clinical use of hyaluronic acid in andrology: A review

Alessandro Zucchi et al. Andrology. 2022 Jan.

Abstract

Background: Hyaluronic acid is a glycosaminoglycan widely used in the fields of orthopedics, ophthalmology, and aesthetic medicine due to its significant ability to reduce the synthesis of pro-inflammatory proteins and its activity against oxidative stress, a feature of many degenerative illnesses.

Objectives: The objective of the present review is to provide a comprehensive narrative review of the most recent literature on the use of hyaluronic acid in andrology in order to facilitate the use of this therapeutic device in the common clinical practice of many physicians. Specific conditions covered in the review are Peyronie's disease, premature ejaculation, and penile enlargement.

Materials and methods: A broad and comprehensive literature search included Medline, EMBASE, and the Cochrane Libraries, with no time restriction up to December 2020 and restricted to English language publications. Unpublished studies were not included. The study was registered as "The role of hyaluronic acid in andrology: A systematic review and meta-analysis" in PROSPERO with the ID CRD42021223416.

Discussion and conclusion: Hyaluronic acid is a valid choice for the treatment of Peyronie's disease in terms of the resolution of the acute phase of the disease and of contributing to stabilizing the disease as a bridge to potential surgery. Data, furthermore, suggest that hyaluronic acid is frequently associated with an overall clinical improvement, allowing the patient to resume normal sexual activity. With regard to premature ejaculation, data suggests hyaluronic acid-based treatments were effective in prolonging intra-vaginal ejaculation time. Furthermore, hyaluronic acid was found to be safe and well-tolerated, with main adverse events limited to local discomfort, ecchymosis, papule formation, and glans numbness, all of which were reported to resolve spontaneously. Last, with regard to penile enlargement, the overall perception of experts is that hyaluronic acid may be an extremely well-tolerated compound with potential for application in specific areas of male sexual health that are often neglected as compared to more common, and relatively simpler to treat, conditions.

Keywords: Peyronie's disease; hyaluronic acid; penile enlargement; premature ejaculation.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Different results using hyaluronic acid in the treatment of Peyronie's disease
FIGURE 2
FIGURE 2
Different results using hyaluronic acid in the treatment of premature ejaculation
See this image and copyright information in PMC

References

    1. Chen CPC, Hsu CC, Pei YC, et al. Changes of synovial fluid protein concentrations in supra‐patellar bursitis patients after the injection of different molecular weights of hyaluronic acid. Exp Gerontol. 2014;52:30‐35. - PubMed
    1. Henrotin Y, Kurz B, Aigner T. Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage. 2005;13:643‐654. - PubMed
    1. Henrotin YE, Bruckner P, Pujol JP. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage. 2003;11:747‐755. - PubMed
    1. Afonso V, Champy R, Mitrovic D, Collin P, Lomri A. Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine. 2007;74:324‐329. - PubMed
    1. Asada S, Fukuda K, Oh M, Hamanishi C, Tanaka S. Effect of hydrogen peroxide on the metabolism of articular chondrocytes. Inflamm Res. 1999;48:399‐403. - PubMed

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