Volume control: Turning the dial on regulatory T cells

Chrysothemis C Brown¹, Rachel A Gottschalk²

Affiliations

¹ Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: brownc10@mskcc.org.
² Department of Immunology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: rachel.gottschalk@pitt.edu.

PMID: 34297928
DOI: 10.1016/j.cell.2021.06.015

Free article

Comment

Volume control: Turning the dial on regulatory T cells

Chrysothemis C Brown et al. Cell. 2021.

Free article

. 2021 Jul 22;184(15):3847-3849.

doi: 10.1016/j.cell.2021.06.015.

Authors

Chrysothemis C Brown¹, Rachel A Gottschalk²

Affiliations

¹ Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: brownc10@mskcc.org.
² Department of Immunology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Center for Systems Immunology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: rachel.gottschalk@pitt.edu.

PMID: 34297928
DOI: 10.1016/j.cell.2021.06.015

Abstract

Treg-mediated immunosuppression must be tightly regulated to support immunity while limiting tissue damage. In this issue of Cell, Wong et al. and Marangoni et al. use high-resolution imaging to define feedback circuits that quantitatively control local Treg expansion and function.

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A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.
Wong HS, Park K, Gola A, Baptista AP, Miller CH, Deep D, Lou M, Boyd LF, Rudensky AY, Savage PA, Altan-Bonnet G, Tsang JS, Germain RN. Wong HS, et al. Cell. 2021 Jul 22;184(15):3981-3997.e22. doi: 10.1016/j.cell.2021.05.028. Epub 2021 Jun 21. Cell. 2021. PMID: 34157301 Free PMC article.
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, Di Pilato M, Othy S, Mempel TR. Marangoni F, et al. Cell. 2021 Jul 22;184(15):3998-4015.e19. doi: 10.1016/j.cell.2021.05.027. Epub 2021 Jun 21. Cell. 2021. PMID: 34157302 Free PMC article.

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Volume control: Turning the dial on regulatory T cells

Affiliations

Volume control: Turning the dial on regulatory T cells

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Abstract

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