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. 2021 Sep 14;16(9):2037-2043.
doi: 10.1016/j.stemcr.2021.06.015. Epub 2021 Jul 22.

Organs-on-chip: The way forward

Massimo Mastrangeli  1 , Janny van den Eijnden-van Raaij  2
Affiliations

Organs-on-chip: The way forward

Massimo Mastrangeli et al. Stem Cell Reports. .

Abstract

Organ-on-chip (OoC) technology is thriving thanks to stem cells availability and international OoC programs. Concerted standardization, qualification, and independent testing of devices are needed to coherently develop OoC technology further and fulfill its potential in drug development, disease modeling, and personalized medicine. The OoC roadmap can lead the way forward.

Keywords: disease modeling; drug development; microphysiological systems; organ-on-chip; personalized medicine; qualification; roadmap; standardization; stem cell.

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Figures

Figure 1
Figure 1
The European OoC roadmap From Mastrangeli et al. (2019b) under Creative Commons License.
Figure 2
Figure 2
Examples of OoC platforms (A) Fabricated parts (upper panel) and full assembly (lower panel) of the Translational OoC Platform (TOP). Adapted from Vollertsen et al. (2020) under Creative Commons License. (B) Predict96, the high-throughput OoC platform with integrated pumping and sensing from Draper. Adapted from Azizgolshani et al. (2021), published by The Royal Society of Chemistry. (C) The four functional layers of the Moore4Medical's Smart Multi-Well Plate (SMWP) platform (an animated illustration of the SMWP concept and architecture is available at https://youtu.be/H595oGbMdyM). Credit: Moore4Medical ECSEL JU.
See this image and copyright information in PMC

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