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Review
. 2021 Jul 20;13(14):3634.
doi: 10.3390/cancers13143634.

Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma

Clara Bertuzzi  1 , Elena Sabattini  1 , Claudio Agostinelli  1   2
Affiliations
Review

Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma

Clara Bertuzzi et al. Cancers (Basel). .

Abstract

Classical Hodgkin's lymphoma (cHL) accounts for 10% of all lymphoma diagnosis. The peculiar feature of the disease is the presence of large multinucleated Reed-Sternberg and mononuclear Hodgkin cells interspersed with a reactive microenvironment (ME). Due to the production of a large number of cytokines, Hodgkin cells (HCs) and Hodgkin Reed-Sternberg cells (HRSCs) attract and favour the expansion of different immune cell populations, modifying their functional status in order to receive prosurvival stimuli and to turn off the antitumour immune response. To this purpose HRSCs shape a biological niche by organizing the spatial distribution of cells in the ME. This review will highlight the contribution of the ME in the pathogenesis and prognosis of cHL and its role as a possible therapeutic target.

Keywords: Hodgkin lymphoma; immune escape; immune surveillance; microenvironment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Representation of the Hodgkinian niche with CD30+ HRSC surrounded by several subsets of Th-1 and T-reg CD4+ lymphocytes, CD8+ cytotoxic T-cell, tumour associated macrophages (TAMs), granulocytes (GRs) and mast cells (MCs).
See this image and copyright information in PMC

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