Competing interests: MA has received consulting fees from ResMed, Philips Respironics, Boehringer Ingelheim, NRI, Novartis, JAZZ Pharmaceuticals, Bayer, Inspire and Bresotec, and grant support from ResMed Foundation, ResMed, Philips Respironics and Else-Kroehner Fresenius Foundation (2018_A159), outside the submitted work. WJR has received consulting fees from Philips respironics, Jazz Pharmaceuticals and Bioprojet and honoraria from Weinmann, Heinen & Löwenstein, Bioprojet, Philips Respironics, Jazz Pharmaceuticals and support for attending meetings from Heinen & Löwenstein, Inspire, Philips Respironics, Bioprojet.