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Comment
. 2021 Sep;599(17):4015-4016.
doi: 10.1113/JP282061. Epub 2021 Aug 12.

One step closer to pharmacotherapy for sleep apnoea

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Free article
Comment

One step closer to pharmacotherapy for sleep apnoea

Ken D O'Halloran. J Physiol. 2021 Sep.
Free article
No abstract available

Keywords: genioglossus; hyoscine buytlbromide; randomised-controlled trial; reboxetine; sleep-disordered breathing.

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References

    1. Aishah A, Lim R, Sands SA, Taranto-Montemurro L, Wellman A, Carberry JC & Eckert DJ (2021). Different antimuscarinics when combined with atomoxetine have differential effects on obstructive sleep apnea severity. J Appl Physiol 130, 1373-1382.
    1. Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, Nunez CM, Patel SR, Penzel T, Pépin JL, Peppard PE, Sinha S, Tufik S, Valentine K & Malhotra A (2019). Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med 7, 687-698.
    1. Grace KP, Hughes SW & Horner RL (2013). Identification of the mechanism mediating genioglossus muscle suppression in REM sleep. Am J Respir Crit Care Med 187, 311-319.
    1. Lim R, Carberry JC, Wellman A, Grunstein R & Eckert DJ (2019). Reboxetine and hyoscine butylbromide improve upper airway function during nonrapid eye movement and suppress rapid eye movement sleep in healthy individuals. Sleep 42, zsy261.
    1. Lim R, Messineo L, Grunstein RR, Carberry JC & Eckert DJ (2021). The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep apnoea severity: A double-blind, placebo-controlled, randomised crossover trial. J Physiol 599, 4183-4195.

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