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. 2021 Nov;59(9):1099-1101.
doi: 10.1016/j.bjoms.2021.02.019. Epub 2021 Mar 3.

Malignant transformation in a cohort of patients with oral epithelial dysplasia

P M Hankinson  1 , R I Mohammed-Ali  2 , A T Smith  3 , S A Khurram  4
Affiliations

Malignant transformation in a cohort of patients with oral epithelial dysplasia

P M Hankinson et al. Br J Oral Maxillofac Surg. 2021 Nov.

Abstract

Oral epithelial dysplasia (OED) is often diagnosed in oral potentially malignant disorders (OPMD) and carries an increased risk of malignant transformation. Currently, the reported risk of malignant transformation for OED varies. Here we present the risk in a cohort of 150 patients with OED at a specialist centre. In this cohort 2.6%, 4.1%, and 29.2% cases of mild, moderate, and severe OED, respectively, progressed to oral squamous cell carcinoma at the dysplastic site, while a small number developed a malignant lesion elsewhere. Moreover, 17 patients experienced an increase in grade of dysplasia and two showed histological resolution of their lesions.

Keywords: Malignant transformation; oral epithelial dysplasia; oral potentially malignant disorders.

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