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Clinical Trial
. 2022 Jun;20(6):1404-1407.e4.
doi: 10.1016/j.cgh.2021.07.030. Epub 2021 Jul 22.

Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial

Tjitske S R Van Engelen  1 , Jack Yang  2 , Bastiaan W Haak  2 , Peter I Bonta  3 , Tom Van Der Poll  4 , W Joost Wiersinga  4 ; CAST study group
Collaborators, Affiliations
Free article
Clinical Trial

Gut Microbiome Modulation by Antibiotics in Adult Asthma: A Human Proof-of-Concept Intervention Trial

Tjitske S R Van Engelen et al. Clin Gastroenterol Hepatol. 2022 Jun.
Free article

Abstract

Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.1 Disruption and subsequent dysregulation of gut microbiota-related immunologic processes have also been linked to disease severity and response to treatment.2.

Trial registration: ClinicalTrials.gov NCT03051698.

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