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. 2021 Nov;63(11):1925-1934.
doi: 10.1007/s00234-021-02765-0. Epub 2021 Jul 25.

Magnetic resonance features and cranial nerve involvement in pediatric head and neck rhabdomyosarcomas

Giacomo Talenti #  1 , Stefania Picariello #  2   3 , Caroline Robson  4 , Livja Mertiri  5   6 , Carmela Russo  7 , Olga Slater  3 , Sotirios Bisdas  8 , Massimo Eraldo Abate  9 , Silverio Perrotta  2 , Richard Hewitt  10 , Kshitij Mankad  5 , Felice D'Arco  5
Affiliations

Magnetic resonance features and cranial nerve involvement in pediatric head and neck rhabdomyosarcomas

Giacomo Talenti et al. Neuroradiology. 2021 Nov.

Erratum in

Abstract

Purpose: Rhabdomyosarcoma (RMS) is a malignant tumor frequent in children. The frequency and characteristics of cranial nerve involvement in pediatric head and neck (H&N) RMS have been scarcely reported. The aim of this study is to review a large cohort of pediatric head and neck RMS with an emphasis on cranial nerve involvement.

Methods: We retrospectively reviewed H&N RMS cases from 3 tertiary hospitals over a 10-year period. Cranial nerve involvement was defined as radiologically apparent tumor extension along a nerve and/or the presence of secondary signs. Scans were reviewed by two pediatric neuroradiologists, blinded to clinical data.

Results: A total of 52 patients met the inclusion criteria. Histologically, 39/52 were embryonal RMS, while 13/52 were alveolar RMS. Regional lymph nodes metastases were present in 19.2%. Cranial nerve involvement was present in 36.5%. Nerves were mainly involved as a direct extension of the mass through skull base foramina or after invasion of cavernous sinus, Meckel's cave, orbital apex, or stylomastoid foramen.

Conclusion: Cranial nerve involvement is frequent in pediatric head and neck RMS and occurs secondary to "geographic" invasion due to direct extension through skull base foramina or cavernous sinus. These tumors never showed distant perineural metastatic disease as is seen in cases of adult head and neck carcinomas. This implies a different biological interaction between the nerves and these tumors in comparison to adult H&N tumors.

Keywords: Alveolar rhabdomyosarcoma; Embryonal rhabdomyosarcoma; Head and neck tumors; Pediatric neck tumors; Perineural tumor spread.

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References

    1. Jawad N, McHugh K (2019) The clinical and radiologic features of paediatric rhabdomyosarcoma. Pediatr Radiol 4911:1516–1523 - DOI
    1. Freling NJM, Merks JHM, Saeed P et al (2010) Imaging findings in craniofacial childhood rhabdomyosarcoma. Pediatr Radiol 4011:1723–38; quiz 1855 - DOI
    1. Dankbaar JW, Pameijer FA, Hendrikse J et al (2018) Easily detected signs of perineural tumour spread in head and neck cancer. Insights Imaging 96:1089–1095 - DOI
    1. Bakst RL, Glastonbury CM, Parvathaneni U et al (2019) Perineural invasion and perineural tumor spread in head and neck cancer. Int J Radiat Oncol Biol Phys 1035:1109–1124 - DOI
    1. Curtin HD (1998) Detection of perineural spread: fat is a friend. AJNR Am J Neuroradiol 198:1385–1386

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