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. 2021 Jul;48(7):5775-5785.
doi: 10.1007/s11033-021-06578-5. Epub 2021 Jul 24.

Anticancer activity of monoterpenes: a systematic review

Bruno I M Silva  1 , Erika A Nascimento  1 , Cleber J Silva  1 , Teresinha G Silva  1 , Jaciana S Aguiar  2
Affiliations

Anticancer activity of monoterpenes: a systematic review

Bruno I M Silva et al. Mol Biol Rep. 2021 Jul.

Abstract

Secondary metabolites have been recognized for centuries as medicinal agents, in particular monoterpenes which have been the target of research in the discovery of antineoplastic drugs, as they have potential antitumor effect and low toxicity and are used as additives in foods and cosmetics. Another advantage of monoterpenes is structural diversity, which gives greater plasticity when interacting with cells. The purpose of this review was to summarize and critically discuss the anticancer potential of monoterpenes and their respective mechanisms of action. A systematic review of articles in the MEDLINE/PubMed, Web of Science, Scopus and Science Direct electronic databases was independently conducted by three reviewers using the combination of the following keywords: monoterpenes AND anticancer AND in vitro. Restriction in selecting articles followed pre-established inclusion and exclusion criteria by the reviewers, and also a time limitation with works published between 2015 and 2019 being selected. In total, 39 works were deemed eligible for inclusion in the final review. Monoterpenes have cytotoxic activity in a wide variety of tumor cell lines, and mainly appear to exert this effect by inducing apoptosis caused by oxidative stress. In addition, improved use of monoterpenes when used in drug delivery systems and the synergistic effect with conventional chemotherapeutic drugs are reported. These findings validate this class of compounds as a promising source of chemotherapeutic drugs yet to be explored.

Keywords: Antineoplastic; Apoptosis; Cytotoxicity; Iridoids; Oxidative stress.

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References

    1. Bray F, Ferlay J, Soerjomataram I et al (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424. https://doi.org/10.3322/caac.21492 - DOI - PubMed - PMC
    1. Oturanel CE, Kıran İ, Özşen Ö et al (2017) Cytotoxic, antiproliferative and apoptotic effects of perillyl alcohol and its biotransformation metabolite on A549 and HepG2 cancer cell lines. Anticancer Agents Med Chem 17:1243–1250. https://doi.org/10.2174/1871520617666170103093923 - DOI - PubMed
    1. Shrestha S, Song YW, Kim H et al (2016) Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells. Phytomedicine 23:1671–1679. https://doi.org/10.1016/j.phymed.2016.09.008 - DOI - PubMed
    1. Deb DD, Parimala G, Saravana Devi S, Chakraborty T (2011) Effect of thymol on peripheral blood mononuclear cell PBMC and acute promyelotic cancer cell line HL-60. Chem Biol Interact 193:97–106. https://doi.org/10.1016/j.cbi.2011.05.009 - DOI - PubMed
    1. Brahmkshatriya PP, Brahmkshatriya PS (2013) Terpenes: chemistry, biological role, and therapeutic applications. In: Ramawat KG, Mérillon JM (eds) Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. Springer, New York, pp 2665–2691 - DOI

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