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Case Reports
. 2021 Jul 9:12:676497.
doi: 10.3389/fgene.2021.676497. eCollection 2021.

Case Report: Triple Primary Malignant Tumors of the Esophagus, Stomach, and Colon in a Patient With Genetic Analysis

Xiaoli Zhan  1 , Lingzhe He  1 , Kai Song  2 , Shuliang Cao  3 , Erhong Meng  3 , Yuedong Wang  1
Affiliations
Case Reports

Case Report: Triple Primary Malignant Tumors of the Esophagus, Stomach, and Colon in a Patient With Genetic Analysis

Xiaoli Zhan et al. Front Genet. .

Abstract

The incidence of multiple primary malignant tumors (MPMTs) has increased greatly with the progress of tumor diagnosis and therapy technology. However, triple primary cancer is still very rare, and its genetic change is not clear yet. This case report described a 70-year-old Chinese male patient with triple primary cancers of the esophagus, stomach and right-sided colon. Pathological examination confirmed that each malignant tumor developed independently. Next-generation sequencing (NGS) using a 599-gene panel revealed five TP53 mutations in three tumor tissues. These variations might contribute to development of the triple primary malignant tumors in the patient. The patient underwent laparoscopic feeding jejunostomy and postoperative radiotherapy for synchronous esophageal and gastric carcinomas. Then, he underwent laparoscopic-assisted resection of right-sided colonic cancer and lysis of abdominal adhesions. By the time of submitting this manuscript, the patient had been well and no sign of recurrence or metastasis had been observed. To the best of our knowledge, this case is the first one to clarify the genetic abnormalities of triple primary cancers of esophagus, stomach and colon in a Chinese patient. It may contribute to understanding the molecular pathogenesis of multiple primary digestive malignancies and providing valuable treatment strategies for the similar patients in the future.

Keywords: colon cancer; esophagus cancer; gastric cancer; genetics; multiple primary malignant tumors.

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Conflict of interest statement

SC and EM are employees at ChosenMed Technology. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Esophagogastroduodenoscopic, Colonoscopic, and microscopic morphology of esophageal carcinoma, gastric carcinoma as well as colon cancer. (A) Esophagogastroduodenoscopic morphology of esophageal carcinoma. (B) Pathological examination showed esophageal squamous cell carcinoma (H.E. × 100). (C) Esophagogastroduodenoscopic morphology of gastric carcinoma. (D) Pathological examination revealed well-differentiated gastric adenocarcinoma (H.E. × 100). (E) Colonoscopic morphology of right-sided colon. (F) Pathological examination showed moderately differentiated adenocarcinoma of colon (H.E. × 100).
Figure 2
Figure 2
Timeline of the patient.
See this image and copyright information in PMC

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