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Case Reports
. 2021 Summer;16(3):332-336.
doi: 10.30699/IJP.2020.131638.2463. Epub 2021 May 9.

Severe Prekallikrein Deficiency Associated with Low Level of Factor XII: A Case Report

Massoumeh Shahbazi  1 , Minoo Ahmadinejad  1 , Shahnaz Fakhrzadegan  2
Affiliations
Case Reports

Severe Prekallikrein Deficiency Associated with Low Level of Factor XII: A Case Report

Massoumeh Shahbazi et al. Iran J Pathol. 2021 Summer.

Abstract

Hereditary deficiency of plasma prekallikrein (PPK) is a rare autosomal recessive disease. The affected patients are often asymptomatic and diagnosed incidentally during preoperative investigations or during hospitalization by isolated prolongation of activated partial thromboplastin time (aPTT). In this article, we report, a 46-year-old woman who was candidate for two invasive procedures (thyroid FNA and hysterectomy) and underwent preoperative evaluation. Due to prolonged aPTT with normal PT she was referred to the IBTO reference coagulation laboratory for specific coagulation assays. Ultimately, the examinations revealed severe PPK deficiency (<1%) with partial deficiency of factor XII level (25%).

Keywords: Factor XII deficiency; Prekallikrein deficiency; Prolonged aPTT.

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Conflict of interest statement

The authors declared that there is no conflict of interest regarding the publication of this article.

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