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Case Reports
. 2021 Jun 24:33:18-20.
doi: 10.1016/j.mmcr.2021.06.002. eCollection 2021 Sep.

Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis

Alfredo G Puing  1 , Shyam S Raghavan  2 , Maria A Aleshin  3 , Dora Y Ho  4
Affiliations
Case Reports

Hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis

Alfredo G Puing et al. Med Mycol Case Rep. .

Abstract

Histoplasmosis-associated hemophagocytic lymphohistiocytosis is a rate but lethal disease in immunocompromised hosts. Unusual clinical presentations make diagnosing invasive fungal infection even more challenging. Here we present a case of hemophagocytic lymphohistiocytosis secondary to progressive disseminated histoplasmosis presenting as cellulitis in a patient with systemic lupus erythematous. A high index of suspicion combined with histopathology and molecular diagnostic techniques are important to establish an accurate and timely diagnosis of opportunistic infections in immunocompromised patients.

Keywords: Cellulitis; Hemophagocytic lymphohistiocytosis; Histoplasma; Histoplasmosis; Lupus.

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Conflict of interest statement

There are none.

Figures

Fig. 1
Fig. 1
Prominent edematous striae and extensive pink indurated plaque on the right lower abdomen. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2
Fig. 2
High power periodic acid-Schiff stain of the abdominal skin biopsy revealed a perivascular infiltrate of histiocytes (black arrow) with scattered small yeast forms (red arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

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