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Case Reports
. 2021 Jun;8(3):134-137.
doi: 10.1159/000514112. Epub 2021 Mar 8.

Anal Cancer with Mediastinal Lymph Node Metastasis

Mangalore Amith Shenoy  1 , Lydia Winnicka  1 , Leili Mirsadraei  2 , Douglas Marks  3
Affiliations
Case Reports

Anal Cancer with Mediastinal Lymph Node Metastasis

Mangalore Amith Shenoy et al. Gastrointest Tumors. 2021 Jun.

Abstract

Squamous cell carcinoma of the anal canal remains rare, with metastatic disease even less commonly reported. We present a case of a patient with both a prior history of squamous cell carcinoma of the anal canal as well as breast cancer, who was without evidence of disease for 1 year. She was subsequently found to have FDG-avid mediastinal lymphadenopathy, initially assumed to be related to her more recent breast cancer. However, a biopsy confirmed recurrent anal cancer, with HPV infection. This represents a novel site of spread for anal cancer, one not yet reported in the literature.

Keywords: Anal cancer; Biopsy; Colorectal cancer; Imaging; Metastasis.

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Conflict of interest statement

The authors have no conflicts of interest to disclose, financial or otherwise.

Figures

Fig. 1
Fig. 1
Station 7 (subcarinal) FDG-avid lymphadenopathy. FDG, fluorodeoxyglucose.
Fig. 2
Fig. 2
Tightly cohesive clusters of squamous cells with nuclear pleomorphism in a necrotic background.
Fig. 3
Fig. 3
Positive immunohistochemical stain for HPV. HPV, human papilloma virus.
See this image and copyright information in PMC

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