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Review
. 2021 Jul 7:9:653296.
doi: 10.3389/fcell.2021.653296. eCollection 2021.

The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes

Soudeh Ghafouri-Fard  1 , Vahid Niazi  2 , Bashdar Mahmud Hussen  3 , Mir Davood Omrani  1 , Mohammad Taheri  4 , Abbas Basiri  5
Affiliations
Review

The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes

Soudeh Ghafouri-Fard et al. Front Cell Dev Biol. .

Abstract

Extracellular vesicles (EVs) are produced by diverse eukaryotic and prokaryotic cells. They have prominent roles in the modulation of cell-cell communication, inflammation versus immunomodulation, carcinogenic processes, cell proliferation and differentiation, and tissue regeneration. These acellular vesicles are more promising than cellular methods because of the lower risk of tumor formation, autoimmune responses and toxic effects compared with cell therapy. Moreover, the small size and lower complexity of these vesicles compared with cells have made their production and storage easier than cellular methods. Exosomes originated from mesenchymal stem cells has also been introduced as therapeutic option for a number of human diseases. The current review aims at summarization of the role of EVs in the regenerative medicine with a focus on their therapeutic impacts in liver fibrosis, lung disorders, osteoarthritis, colitis, myocardial injury, spinal cord injury and retinal injury.

Keywords: biomarkers; expression; extracellular medicine; mesenchymal stem cells; regenerative medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Role of MSC-derived extracellular vesicles in the regeneration of different tissues.
See this image and copyright information in PMC

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