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. 2021 Jul 6;9(19):5179-5190.
doi: 10.12998/wjcc.v9.i19.5179.

Systematic review and meta-analysis of trans-jugular intrahepatic portosystemic shunt for cirrhotic patients with portal vein thrombosis

Jian-Bin Zhang  1 , Jie Chen  1 , Jin Zhou  1 , Xu-Ming Wang  1 , Shu Chen  2 , Jian-Guo Chu  3 , Peng Liu  1 , Zhi-Dong Ye  4
Affiliations

Systematic review and meta-analysis of trans-jugular intrahepatic portosystemic shunt for cirrhotic patients with portal vein thrombosis

Jian-Bin Zhang et al. World J Clin Cases. .

Abstract

Background: Portal vein thrombosis (PVT) was previously a contraindication for trans-jugular intrahepatic portosystemic shunt (TIPS).

Aim: To perform a systematic review and meta-analysis of the current available studies investigating outcomes of TIPS for cirrhotic patient with PVT.

Methods: Multiple databases were systematically searched to identify studies investigating the outcomes of TIPS for cirrhotic patients with PVT. The quality of studies was assessed by Cochrane Collaboration method and Methodological Index for Non-Randomized Studies. The demographic data, outcomes, combined treatment, and anticoagulation strategy were extracted.

Results: Twelve studies were identified with 460 patients enrolled in the analysis. The technical success rate was 98.9% in patients without portal vein cavernous transformation and 92.3% in patients with portal vein cavernous transformation. One-year portal vein recanalization rate was 77.7%, and TIPS patency rate was 84.2%. The cumulative encephalopathy rate was 16.4%. One-year overall survival was 87.4%.

Conclusion: TIPS is indicated for portal hypertension related complications and the restoration of pre-transplantation portal vein patency in cirrhotic patients with PVT. Cavernous transformation is an indicator for technical failure. Post-TIPS anticoagulation seems not mandatory. Simultaneous TIPS and percutaneous mechanical thrombectomy device could achieve accelerated portal vein recanalization and decreased thrombolysis-associated complications, but further investigation is still needed.

Keywords: Liver cirrhosis; Meta-analysis; Portal vein thrombosis; Systematic review; Trans-jugular intrahepatic portosystemic shunt.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interests or financial disclosures relevant to this manuscript.

Figures

Figure 1
Figure 1
PRISMA flow chart for the selection process. TIPS: Trans-jugular intrahepatic portosystemic shunt.
Figure 2
Figure 2
Forrest plots of pooled analysis. A: Technical success rate without portal vein cavernous transformation; B: Technical success rate with portal vein cavernous transformation; C: 1-yr portal vein recanalization rate; D: 1-yr TIPS patency rate; E: 1-yr encephalopathy rate; F: 1-yr survival rate. CI: Confidence interval; TIPS: Trans-jugular intrahepatic portosystemic shunt.
See this image and copyright information in PMC

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