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Review
. 2021 Jul 7:2021:6708865.
doi: 10.1155/2021/6708865. eCollection 2021.

Global Burden of Anxiety and Depression among Cystic Fibrosis Patient: Systematic Review and Meta-Analysis

Mistire Teshome Guta  1 , Tiwabwork Tekalign  1 , Nefsu Awoke  1 , Robera Olana Fite  2 , Getahun Dendir  3 , Tsegaye Lolaso Lenjebo  4
Affiliations
Review

Global Burden of Anxiety and Depression among Cystic Fibrosis Patient: Systematic Review and Meta-Analysis

Mistire Teshome Guta et al. Int J Chronic Dis. .

Abstract

Aims: This systemic review and meta-analysis were aimed at determining the level of anxiety and depression among cystic fibrosis patients in the world.

Methods: We conducted a systematic search of published studies from PubMed, EMBASE, MEDLINE, Cochrane, Scopus, Web of Science, CINAHL, and manually on Google Scholar. This meta-analysis follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of studies was assessed by the modified Newcastle-Ottawa Scale (NOS). Meta-analysis was carried out using a random-effects method using the STATA™ Version 14 software. Trim and fill analysis was done to correct the presence of significant publication bias.

Result: From 419,820 obtained studies, 26 studies from 2 different parts of the world including 9766. The overall global pooled prevalence of anxiety and depression after correction for publication bias by trim and fill analysis was found to be 24.91(95% CI: 20.8-28.9) for anxiety. The subgroup analyses revealed with the lowest prevalence, 23.59%, (95% CI: 8.08, 39.09)) in North America and the highest, 26.77%, (95% CI: 22.5, 31.04) seen in Europe for anxiety and with the highest prevalence, 18.67%, (95% CI: 9.82, 27.5) in North America and the lowest, 13.27%, (95% CI: -10.05, 16.5) seen in Europe for depression.

Conclusion: The global prevalence of anxiety and depression among cystic fibrosis patients is common. Therefore, close monitoring of the patient, regularly screening for anxiety and depression, and appropriate prevention techniques is recommended.

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Conflict of interest statement

All the authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
PRISMA flow diagram of study selection.
Figure 2
Figure 2
Forest plot showing global pooled prevalence of anxiety in patients with cystic fibrosis.
Figure 3
Figure 3
Forest plot showing global pooled prevalence of depression in patients with cystic fibrosis.
Figure 4
Figure 4
Subgroup analysis of global prevalence of anxiety in patients with cystic fibrosis.
Figure 5
Figure 5
Subgroup analysis of global prevalence of depression in patients with cystic fibrosis.
Figure 6
Figure 6
Funnel plot to test the publication bias in 24 studies of anxiety with 95% confidence limits.
Figure 7
Figure 7
Funnel plot to test the publication bias of depression in 26 studies with 95% confidence limits.
See this image and copyright information in PMC

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