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. 2021 Jul 15;16(1):703-710.
doi: 10.1515/biol-2021-0069. eCollection 2021.

Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning

Yuhang Mu  1 , Boqi Hu  2 , Nan Gao  3 , Li Pang  1
Affiliations

Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning

Yuhang Mu et al. Open Life Sci. .

Abstract

This study investigates the ability of blood neutrophil-to-lymphocyte ratio (NLR) to predict acute organophosphorus pesticide poisoning (AOPP). Clinical data of 385 patients with AOPP were obtained within 24 h of admission, and NLR values were calculated based on neutrophil and lymphocyte counts. The patients were divided into two groups - good and poor - based on prognosis. Poor prognosis included in-hospital death and severe poisoning. The factors affecting prognosis were analyzed by logistic regression analysis, and the prognostic value of NLR was evaluated using the area under the receiver operating characteristic curve (AUC). Univariate logistic regression analysis showed that NLR levels, serum cholinesterase, and creatinine levels were good predictors of AOPP. Multivariate logistic regression analysis showed that high NLR was an independent risk factor for severe poisoning (adjusted odds ratio [AOR], 1.13; 95% CI, 1.10-1.17; p < 0.05) and in-hospital mortality (AOR, 1.07; 95% CI, 1.03-1.11; p < 0.05). NLR values >13 and >17 had a moderate ability to predict severe poisoning and in-hospital mortality, respectively (AUC of 0.782 [95% CI, 0.74-0.824] and 0.714 [95% CI, 0.626-0.803], respectively). Our results show that high NLR at admission is an independent indicator of poor prognosis in AOPP and can be used to optimize treatment and manage patients.

Keywords: AOPP; NLR; prognosis; public health; risk factor.

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Conflict of interest statement

Conflict of interest: The authors state no conflict of interest.

Figures

Figure 1
Figure 1
Patient selection.
Figure 2
Figure 2
Area under the receiver operating characteristic curve of the neutrophil-to-lymphocyte ratio (NLR) for predicting severe poisoning and in-hospital mortality. NLR with cutoff values.
Figure 3
Figure 3
Area under the receiver operating characteristic curve for severe poisoning (a) and death (b).
See this image and copyright information in PMC

References

    1. Mew EJ, Padmanathan P, Konradsen F, Eddleston M, Chang SS, Phillips MR, et al. The global burden of fatal self-poisoning with pesticides 2006–15: systematic review. J Affect Disord. 2017;219:93–104. 10.1016/j.jad.2017.05.002. - DOI - PubMed
    2. Mew EJ, Padmanathan P, Konradsen F, Eddleston M, Chang SS, Phillips MR. et al. The global burden of fatal self-poisoning with pesticides 2006–15: systematic review. J Affect Disord. 2017;219:93–104. doi: 10.1016/j.jad.2017.05.002. - DOI - PubMed
    1. Wu X, Xie W, Cheng Y, Guan Q. Severity and prognosis of acute organophosphorus pesticide poisoning are indicated by C-reactive protein and copeptin levels and APACHE II score. Exp Ther Med. 2016;11(3):806–10. 10.3892/etm.2016.2982. - DOI - PMC - PubMed
    2. Wu X, Xie W, Cheng Y, Guan Q. Severity and prognosis of acute organophosphorus pesticide poisoning are indicated by C-reactive protein and copeptin levels and APACHE II score. Exp Ther Med. 2016;11(3):806–10. doi: 10.3892/etm.2016.2982. - DOI - PMC - PubMed
    1. Khosravani H, Shahpori R, Stelfox HT, Kirkpatrick AW, Laupland KB. Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill. Crit Care. 2009;13(3):R90. 10.1186/cc7918. - DOI - PMC - PubMed
    2. Khosravani H, Shahpori R, Stelfox HT, Kirkpatrick AW, Laupland KB. Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill. Crit Care. 2009;13(3):R90. doi: 10.1186/cc7918. - DOI - PMC - PubMed
    1. Tallat S, Hussien R, Mohamed RH, Abd El Wahab MB, Mahmoud M. Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning. J Genet Eng Biotechnol. 2020;18(1):10. 10.1186/s43141-020-00024-y. - DOI - PMC - PubMed
    2. Tallat S, Hussien R, Mohamed RH, Abd El Wahab MB, Mahmoud M. Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning. J Genet Eng Biotechnol. 2020;18(1):10. doi: 10.1186/s43141-020-00024-y. - DOI - PMC - PubMed
    1. Dungdung A, Kumar A, Kumar B, Preetam M, Tara RK, Saba MK. Correlation and prognostic significance of serum amylase, serum lipase, and plasma cholinesterase in acute organophosphorus poisoning. J Family Med Prim Care. 2020;9(4):1873–7. 10.4103/jfmpc.jfmpc_205_20. - DOI - PMC - PubMed
    2. Dungdung A, Kumar A, Kumar B, Preetam M, Tara RK, Saba MK. Correlation and prognostic significance of serum amylase, serum lipase, and plasma cholinesterase in acute organophosphorus poisoning. J Family Med Prim Care. 2020;9(4):1873–7. doi: 10.4103/jfmpc.jfmpc_205_20. - DOI - PMC - PubMed

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