Diagnostic Yield of Saliva for SARS-CoV-2 Molecular Testing in Children
- PMID: 34309674
- PMCID: PMC8344893
- DOI: 10.1093/jpids/piab058
Diagnostic Yield of Saliva for SARS-CoV-2 Molecular Testing in Children
Abstract
Pediatric saliva specimen demonstrated high sensitivity (93%) and specificity (96.2%) compared to paired nasopharyngeal swabs (NPS) by Aptima SARS-CoV-2 Assay (Aptima). Viral loads were comparable in both specimen types. Saliva is a safe, noninvasive, and acceptable alternative specimen for SARS-CoV-2 detection in children.
Keywords: SARS-CoV-2; molecular assay; pediatric; saliva.
© The Author(s) 2021. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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References
-
- Ranney ML, Griffeth V, Jha AK. Critical supply shortages—the need for ventilators and personal protective equipment during the covid-19 pandemic. N Engl J Med 2020; 382:e41. - PubMed
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