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. 2021 Aug;8(8):1755-1759.
doi: 10.1002/acn3.51431. Epub 2021 Jul 26.

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

Yeona Kang  1   2 , Sneha Pandya  2 , Nicole Zinger  3 , Nara Michaelson  3 , Susan A Gauthier  2   3   4
Affiliations

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

Yeona Kang et al. Ann Clin Transl Neurol. 2021 Aug.

Abstract

The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS.

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Conflict of interest statement

YK, SP, NM, NZ have nothing to disclose. SG reports grants from Genzyme, during the conduct of the study; grants and personal fees from Genentech, personal fees from Biogen, grants from Mallinckrodt, outside the submitted work.

Figures

Figure 1
Figure 1
Comparison with HC (n = 16) and MS baseline (n = 15) in DVR. PK11195 PET DVR among in VOIs in healthy control (HC) as compare to MS patients at baseline scan. Nine secondary progressive (SP) and six primary progressive (PP) patients included. VOIs included normal‐appearing white matter (NAWM), whole lesion mask (Lesion), cortical gray matter (GM), thalamus (TH), caudate (CAU), putamen (PU), hippocampus (HIPP), and amygdala (AMG). *p < 0.05.
Figure 2
Figure 2
Longitudinal change in PK11195 in progressive MS patients. Longitudinal change in PK11195 PET DVR over the course of 6 (n = 15), and 12 months (n = 14) and 24 months (n = 10). VOIs include normal‐appearing white matter (NAWM), whole lesion mask (Lesion), cortical gray matter (GM), thalamus (TH), caudate (CAU), putamen (PU), hippocampus (HIPP), and amygdala (AMG). *p < 0.05.
See this image and copyright information in PMC

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