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. 1978 Jan;75(1):136-9.
doi: 10.1073/pnas.75.1.136.

Role of the host in virus assembly: cloning of the Escherichia coli groE gene and identification of its protein product

R W Hendrix, L Tsui

Role of the host in virus assembly: cloning of the Escherichia coli groE gene and identification of its protein product

R W Hendrix et al. Proc Natl Acad Sci U S A. 1978 Jan.

Abstract

Correct assembly of the heads of bacteriophages lambda and T4 requires the function of the groE gene of the Escherichia coli host. We have isolated a transducing derivative of lambda, called lambda gt-Ec.groE, that carries a functional copy of the groE gene. Unlike wild-type lambda, this phage is able to form plaques on hosts with a mutant groE gene. We have isolated an amber mutation in the groE gene carried by the phage, and this has made it possible to identify the groE product as a protein of molecular weight 65,000. In the phage, the groE gene is under the control of an early phage promoter.

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