Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Sep;599(18):4247-4248.
doi: 10.1113/JP281999. Epub 2021 Aug 15.

Lessons from on high: arterial CO2 , not pH, is the key mediator of cerebrovascular function

Jack K Leacy  1
Affiliations
Free article
Comment

Lessons from on high: arterial CO2 , not pH, is the key mediator of cerebrovascular function

Jack K Leacy. J Physiol. 2021 Sep.
Free article
No abstract available

Keywords: acid-base balance; carbon dioxide; cerebral blood flow; cerebrovascular reactivity.

PubMed Disclaimer

Comment on

References

    1. Caldwell HG, Howe CA, Chalifoux CJ, Hoiland RL, Carr JMJR, Brown CV, Patrician A, Tremblay JC, Panerai RB, Robinson TG, Minhas JS & Ainslie PN (2021a). Arterial carbon dioxide and bicarbonate rather than pH regulate cerebral blood flow in the setting of acute experimental metabolic alkalosis. J Physiol 599, 1439-1457.
    1. Caldwell HG, Smith KJ, Lewis NCS, Hoiland RL, Willie CK, Lucas SJE, Stembridge M, Burgess KR, MacLeod DB & Ainslie PN (2021b). Regulation of cerebral blood flow by arterial PCO2 independent of metabolic acidosis at 5050 m. J Physiol 599, 3513-3530.
    1. Duffin J, Mikulis DJ & Fisher JA (2021). Control of cerebral blood flow by blood gases. Front Physiol 12, 640075. https://doi.org/10.3389/fphys.2021.640075.
    1. Hoiland RL, Fisher JA & Ainslie PN (2019). Regulation of the cerebral circulation by arterial carbon dioxide. Compr Physiol 9, 1101-1154.
    1. Willie CK, MacLeod DB, Smith KJ, Lewis NC, Foster GE, Ikeda K, Hoiland RL & Ainslie PN (2015). The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude. J Cereb Blood Flow Metab 35, 873-881.

Publication types

LinkOut - more resources