Portable Acquisition of Auditory ERPs: A Pilot Study of Premature Infants

Abstract

Background: Prior work suggests that event-related potential (ERP) studies in infancy may help predict developmental outcome.

Methods: As part of a longitudinal study of early child development, we used the auditory oddball stimulus paradigm with a portable electroencephalography system to obtain ERP data from two-month-old infants (32 term, six preterm) in Sri Lanka. The mismatch negativity was calculated between 200 and 350 milliseconds after stimulus presentation.

Results: We found a significant correlation between birth weight and mismatch negativity (P = 0.046), and our time-frequency analysis indicated power differences between standard and oddball tones at approximately 5 and 18 Hz. There was no significant difference between mismatch negativity in children undergoing ERP studies in a hospital setting (30) versus in the child's home (eight).

Conclusions: Although our modest sample size precludes drawing definitive conclusions, these preliminary results show that it is possible to acquire ERP datasets using currently available portable technology in a hospital or home setting, even in a developing nation such as Sri Lanka. Follow-up of this cohort will include developmental assessments, which will add to the growing literature relating early electrophysiology to developmental outcome.

Keywords: Child development; Early intervention; Evoked potential; Global health; Odd ball; Prematurity; Wearables.