Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?

Meng Guo^{1

2}, Wanyin Tao^{1

2}, Richard A Flavell^{3

4}, Shu Zhu^{5

6

7

8}

Affiliations

¹ Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
² Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
³ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.
⁴ Howard Hughes Medical Institute, Chevy Chase, MD, USA. richard.flavell@yale.edu.
⁵ Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁶ Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁷ School of Data Science, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁸ CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.

PMID: 34312525
PMCID: PMC8311630
DOI: 10.1038/s41575-021-00503-8

Comment

Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?

Meng Guo et al. Nat Rev Gastroenterol Hepatol. 2021 Sep.

. 2021 Sep;18(9):669-670.

doi: 10.1038/s41575-021-00503-8.

Authors

Meng Guo^{1

2}, Wanyin Tao^{1

2}, Richard A Flavell^{3

4}, Shu Zhu^{5

6

7

8}

Affiliations

¹ Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
² Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
³ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.
⁴ Howard Hughes Medical Institute, Chevy Chase, MD, USA. richard.flavell@yale.edu.
⁵ Department of Digestive Disease, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁶ Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁷ School of Data Science, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.
⁸ CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China. zhushu@ustc.edu.cn.

PMID: 34312525
PMCID: PMC8311630
DOI: 10.1038/s41575-021-00503-8

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Comment on

Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.
Guo M, Tao W, Flavell RA, Zhu S. Guo M, et al. Nat Rev Gastroenterol Hepatol. 2021 Apr;18(4):269-283. doi: 10.1038/s41575-021-00416-6. Epub 2021 Feb 15. Nat Rev Gastroenterol Hepatol. 2021. PMID: 33589829 Free PMC article. Review.
Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?
Pedersen RM, Tornby DS, Bang LL, Madsen LW, Skov MN, Jensen TG, Johansen IS, Andersen TE. Pedersen RM, et al. Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):669. doi: 10.1038/s41575-021-00501-w. Nat Rev Gastroenterol Hepatol. 2021. PMID: 34312524 Free PMC article. No abstract available.

References

1. Guo M, Tao W, Flavell RA, Zhu S. Potential intestinal infection and faecal-oral transmission of SARS-CoV-2. Nat. Rev. Gastroenterol. Hepatol. 2021;18:269–283. doi: 10.1038/s41575-021-00416-6. - DOI - PMC - PubMed
1. Pedersen, R. M. et al. Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission? Nat. Rev. Gastroenterol. Hepatol. 10.1038/s41575-021-00501-w (2021). - PMC - PubMed
1. Xiao F, et al. Infectious SARS-CoV-2 in feces of patient with severe COVID-19. Emerg. Infect. Dis. 2020;26:1920–1922. doi: 10.3201/eid2608.200681. - DOI - PMC - PubMed
1. Zhou J, et al. Infection of bat and human intestinal organoids by SARS-CoV-2. Nat. Med. 2020;26:1077–1083. doi: 10.1038/s41591-020-0912-6. - DOI - PubMed
1. Wang W, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323:1843–1844. - PMC - PubMed

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Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?

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Reply to: Rectally shed SARS-CoV-2 lacks infectivity: time to rethink faecal-oral transmission?

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