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Review
. 2021 Jul 26;402(11):1397-1413.
doi: 10.1515/hsz-2021-0170. Print 2021 Oct 26.

Men who stare at bone: multimodal monitoring of bone healing

Sabine Schulze  1   2 , Rebecca Rothe  3   4 , Christin Neuber  3 , Sandra Hauser  3 , Martin Ullrich  3 , Jens Pietzsch  3   4 , Stefan Rammelt  1   2   5
Affiliations
Free article
Review

Men who stare at bone: multimodal monitoring of bone healing

Sabine Schulze et al. Biol Chem. .
Free article

Abstract

Knowledge of the physiological and pathological processes, taking place in bone during fracture healing or defect regeneration, is essential in order to develop strategies to enhance bone healing under normal and critical conditions. Preclinical testing allows a wide range of imaging modalities that may be applied both simultaneously and longitudinally, which will in turn lower the number of animals needed to allow a comprehensive assessment of the healing process. This work provides an up-to-date review on morphological, functional, optical, biochemical, and biophysical imaging techniques including their advantages, disadvantages and potential for combining them in a multimodal and multiscale manner. The focus lies on preclinical testing of biomaterials modified with artificial extracellular matrices in various animal models to enhance bone remodeling and regeneration.

Keywords: ex vivo; in vivo; bone; matrix engineering; remodeling; soft tissue.

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